Altered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder.
Altered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder.
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DOI：
10.1002/brb3.358
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发表时间：
2015-09
影响因子：
3.1
通讯作者：
Wang DJ
中科院分区：
文献类型：
--
作者：
Jann K;Hernandez LM;Beck-Pancer D;McCarron R;Smith RX;Dapretto M;Wang DJ
神经影像学研究可以揭示自闭症谱系障碍（ASD）的神经生物学基础。对静息态脑的研究表明，PET/SPECT的基线代谢发生改变，静息态fMRI的基础上，内在脑网络的功能连接（FC）发生改变。然而，到目前为止，还没有研究共同研究这两个生理参数的静息脑功能，或探讨这些措施和ASD症状严重程度之间的关系。在这里，我们使用伪连续动脉自旋标记与三维背景抑制GRASE评估静息脑血流量（CBF）和FC在17名青少年ASD和22名匹配的典型发展（TD）儿童。ASD与TD儿童的静息灌注改变模式包括背侧前扣带皮层的额颞叶灌注过度和灌注不足。我们发现在默认模式网络（DMN）的前模块中局部FC增加，同时在同一区域CBF减少。在我们的队列中，这两种改变与社会反应量表（SRS-总T评分）评估的更大的社会障碍相关。虽然TD儿童的FC与CBF相关，但ASD儿童的FC与基线灌注之间的这种关联被破坏。此外，ASD儿童的DMN前模块和后模块之间的长程FC减少。总之，这项研究的结果-第一次联合评估ASD的静息CBF和FC-突出了识别ASD血管学新成像标志物的新途径。
Neuroimaging studies can shed light on the neurobiological underpinnings of autism spectrum disorders (ASD). Studies of the resting brain have shown both altered baseline metabolism from PET/SPECT and altered functional connectivity (FC) of intrinsic brain networks based on resting-state fMRI. To date, however, no study has investigated these two physiological parameters of resting brain function jointly, or explored the relationship between these measures and ASD symptom severity. Here, we used pseudo-continuous arterial spin labeling with 3D background-suppressed GRASE to assess resting cerebral blood flow (CBF) and FC in 17 youth with ASD and 22 matched typically developing (TD) children. A pattern of altered resting perfusion was found in ASD versus TD children including frontotemporal hyperperfusion and hypoperfusion in the dorsal anterior cingulate cortex. We found increased local FC in the anterior module of the default mode network (DMN) accompanied by decreased CBF in the same area. In our cohort, both alterations were associated with greater social impairments as assessed with the Social Responsiveness Scale (SRS-total T scores). While FC was correlated with CBF in TD children, this association between FC and baseline perfusion was disrupted in children with ASD. Furthermore, there was reduced long-range FC between anterior and posterior modules of the DMN in children with ASD. Taken together, the findings of this study – the first to jointly assess resting CBF and FC in ASD – highlight new avenues for identifying novel imaging markers of ASD symptomatology.