Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease.
Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease.
复制标题
DOI：
10.1097/wad.0b013e3182163b62
复制
发表时间：
2012-01
影响因子：
2.1
通讯作者：
Thompson PM
中科院分区：
文献类型：
--
作者：
Apostolova LG;Green AE;Babakchanian S;Hwang KS;Chou YY;Toga AW;Thompson PM
阿尔茨海默病(AD)是全世界最常见的痴呆症类型。海马体萎缩和脑室扩大与阿尔茨海默病有关，但也与正常衰老有关。我们分析了46例认知正常老年人(NC)、33例轻度认知障碍(MCI)和43例AD患者的1.5T脑MRI数据。用两种新的半自动分割方法和径向距离标测技术进行了海马体和脑室的分析。用多元线性回归分析年龄和诊断对海马区、脑室体积和径向距离的影响。通过排列测试进行用于多次比较的附加3D地图校正。正如预期的那样，AD组和NC组相比，最显著的海马区萎缩和脑室扩大。MCI受试者表现出中等水平的海马区萎缩和脑室增大。在混合样本中以及在单独考虑的NC和AD组中，年龄对海马体体积和径向距离都有显著影响。在所有海马区和侧脑室的额角和体/枕角部分发现了与年龄相关的差异。衰老对海马区和侧脑室的影响独立于AD病理，在可能的情况下应作为协变量包括在所有结构分析的海马区和脑室中。
Alzheimer's disease (AD) is the most common type of dementia worldwide. Hippocampal atrophy and ventricular enlargement have been associated with AD but also with normal aging. We analyzed 1.5T brain MRI data from 46 cognitively normal elderly (NC), 33 mild cognitive impairment (MCI) and 43 AD subjects. Hippocampal and ventricular analyses were conducted with two novel semi-automated segmentation approaches followed by the radial distance mapping technique. Multiple linear regression was used to assess effects of age and diagnosis on hippocampal and ventricular volumes and radial distance. Additional 3D map correction for multiple comparisons was conducted with permutation testing. As expected, most significant hippocampal atrophy and ventricular enlargement were seen in the AD vs. NC comparison. MCI subjects showed intermediate levels of hippocampal atrophy and ventricular enlargement. Significant effects of age on hippocampal volume and radial distance were seen in the pooled sample as well as in the NC and AD groups considered separately. Age-associated differences were detected in all hippocampal subfields and the frontal and body/occipital horn portions of the lateral ventricles. Aging affects both the hippocampus and lateral ventricles independent of AD pathology and should be included as covariate in all structural hippocampal and ventricular analyses when possible.