Neuroprotective effect of baicalein against MPTP neurotoxicity: Behavioral, biochemical and immunohistochemical profile
Neuroprotective effect of baicalein against MPTP neurotoxicity: Behavioral, biochemical and immunohistochemical profile
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黄芩素对 MPTP 神经毒性的神经保护作用：行为、生化和免疫组织化学特征
DOI：
10.1016/j.neulet.2008.05.116
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发表时间：
2008-08-15
影响因子：
2.5
通讯作者：
Du, Guanhua
中科院分区：
文献类型：
--
作者：
Cheng, Yinxia;He, Guorong;Du, Guanhua
1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）引起多巴胺能神经元的损伤，如在帕金森病（PD）中所见。氧化应激与PD的发病机制有关。从传统中草药黄芩中提取的黄芩素具有抗氧化作用。本文研究了黄芩素对MPTP所致小鼠神经毒性的影响。用黄芩素预处理1周，然后用MPTP连续攻击4天，测定小鼠随后的行为学、生化和免疫组化表现，并与未处理小鼠和仅用MPTP攻击的小鼠进行比较。黄芩素对MPTP所致小鼠行为异常有改善作用。其保护作用可能与提高纹状体DA和5-HT含量、增加多巴胺能神经元数量、抑制氧化应激和星形胶质细胞反应有关。这些结果表明黄芩素具有较强的神经保护活性，可能是一种值得进一步研究的潜在抗帕金森病药物。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes the damage of dopaminergic neurons as seen in Parkinson's disease (PD). Oxidative stress has been implicated in the pathogenesis of PD. Baicalein, isolated from the traditional Chinese herbal medicine Huangqin (Scutellaria baicalensis Georgi) has been, shown to have antioxidant effects. Here we investigated the effect of baicalein on MPTP-induced neurotoxicity in mice. Pretreatment with baicalein for a week was followed by challenge with MPTP for 4 consecutive days; the subsequent behavioral, biochemical and immunohistochemical manifestations in mice were determined and compared to those in untreated mice and mice challenged only with MPTP. The present study showed that baicalein could improve the abnormal behavior in MPTP-treated mice. The protective effect may be caused by increasing the levels of DA and 5-HT in the striatum, increasing the counts of dopaminergic neurons, inhibiting oxidative stress and the astroglia response. These results suggest that baicalein possesses potent neuroprotective activity and may be a potential anti-Parkinson's disease drug that is worthy of further study. (C) 2008 Elsevier Ireland Ltd. All rights reserved.