MUSCLE STIFFNESS DETERMINED FROM CANINE LEFT-VENTRICULAR PRESSURE-VOLUME CURVES
MUSCLE STIFFNESS DETERMINED FROM CANINE LEFT-VENTRICULAR PRESSURE-VOLUME CURVES
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DOI：
10.1161/01.res.37.6.787
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发表时间：
1975-01-01
影响因子：
20.1
通讯作者：
KERNOFF, RS
中科院分区：
文献类型：
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作者：
GLANTZ, SA;KERNOFF, RS
我们测量的压力-容积曲线在9个切除的狗心室和应力-应变曲线在两个到五个肌肉标本从每个心室验证推导公式，肌肉硬度心室压力-容积曲线。这一公式所依据的假设是：（1）心室是一个均匀的球壳，（2）所有的肌纤维承受平均应力并变形，就像它们在中壁一样，（3）静态平衡存在，（4）内压引起唯一的负荷，（5）肌肉表现出由方程sigma（σ）= alpha给出的指数应力-应变曲线（ebeta = 1），其中σ =应力，ε =应变，α和β是常数。从左心室压力-容积曲线（14+/-4.3[SD]）推断的刚度常数β与直接从肌肉应力-应变曲线（16+/-2.8）测量的刚度常数β之间无显著差异。
We measured pressure-volume curves in nine excised dog ventricles and stress-strain curves in two to five muscle specimens from each ventricle to verify a derived formula that relates muscle stiffness to the ventricular pressure-volume curve. The assumptions underlying this formula are: (1) the ventricle is a uniform spherical shell, (2) all muscle fibers carry average stress and deform as if they were at the midwall, (3) static equilibrium exists, (4) internal pressure induces the only load, and (5) the muscles exhibit an exponential stress-strain curve given by the equation sigma(epsilon) = alpha(ebeta epsilon - 1), where sigma = stress, epsilon = strain, and alpha and beta are constants. There was no significant difference between the stiffness constant, beta, inferred from the left ventricle pressure-volume curves (14+/-4.3[SD]) and that measured directly from the muscle stress-strain curves (16+/-2.8).