Glucose administration combined with photodynamic therapy of cancer improves therapeutic efficacy.
Glucose administration combined with photodynamic therapy of cancer improves therapeutic efficacy.
复制标题
葡萄糖给药与癌症光动力疗法相结合可提高治疗效果。
DOI：
10.1002/lsm.1900120207
复制
发表时间：
1992
影响因子：
2.4
通讯作者：
Berns,MW
中科院分区：
文献类型：
--
作者：
Nelson,JS;Kimel,S;Brown,L;Berns,MW
在过去的几年里，PDT的基础研究和临床应用的范围和活动水平都有了巨大的增长。一些研究已经检查了热疗和化疗剂与PDT组合以增强肿瘤根除的协同作用。本研究探讨了葡萄糖给药与光疗相结合的协同作用，本研究的结果表明，葡萄糖给药是简单的，耐受性良好，并与PDT相结合产生了更大的百分比治愈的动物比单独使用PDT。此外，结果表明，这种方法需要较低的光量，并且可能能够减少光敏剂的剂量，以获得对癌症治疗的最佳反应，副作用最小。© 1992 Wiley利斯公司
Both the scope and the levels of activity in basic research and in the clinical applications of PDT, have grown enormously during the past few years. Several studies have examined the synergism of hyperthermia and chemotherapeutic agents in combination with PDT to enhance tumor eradication. The present study investigates the synergism of glucose administration combined with phototherapy.The results of this study suggest that glucose administration is simple and well tolerated, and combined with PDT produces a larger percentage of animals cured than using PDT alone. Furthermore, the results indicate that this approach requires lower amounts of light and might enable dosage reduction of photosensitizer for optimal response, with minimal side effects, to the treatment of cancer. © 1992 Wiley‐Liss, Inc.