ELEMENTAL SULFUR - A NOVEL INHIBITOR OF ADENYLATE KINASE
ELEMENTAL SULFUR - A NOVEL INHIBITOR OF ADENYLATE KINASE
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DOI：
10.1016/0006-291x(83)90472-2
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发表时间：
1983-01-01
影响因子：
3.1
通讯作者：
RUSSELL, PJ
中科院分区：
文献类型：
--
作者：
CONNER, J;RUSSELL, PJ
初级S(S-8)是一种新的、高度特异和有效的[兔肌肉]腺苷酸激酶(AK)抑制剂。S-8对AK的抑制可被二硫苏糖醇完全逆转，并伴随着数倍的酶活性增加。与S-8的SH基团相互作用不是AK抑制剂的作用机制，与N-乙基马来酰亚胺(NEM)的比较抑制研究表明，NEM也不与AK的SH基团相互作用。
Elementary S (S-8) is a novel, highly specific and potent inhibitor of [rabbit muscle] adenylate kinase (AK). The inhibition of AK by S-8 is completely reversed by dithiothreitol and is accompanied by several-fold increases in enzymatic activity. SH group interaction with S-8 does not appear to be the mechanism of AK inhibitor and comparative inhibition studies with N-ethyl maleimide (NEM) indicate that NEM also does not interact with the SH group of AK.