Roles of the NF-κB Pathway in Lymphocyte Development and Function
Roles of the NF-κB Pathway in Lymphocyte Development and Function
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DOI：
10.1101/cshperspect.a000182
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发表时间：
2010-05-01
影响因子：
7.2
通讯作者：
Siebenlist, Ulrich
中科院分区：
文献类型：
--
作者：
Gerondakis, Steve;Siebenlist, Ulrich
本文重点介绍nf - κ B对淋巴细胞和适应性免疫的重要作用。nf - κ B长期以来被认为是成熟淋巴细胞对入侵病原体的许多反应所必需的。此外，NF-kappa B在塑造免疫系统方面具有重要功能，因此它能够对病原体产生适应性反应。在这两种情况下，NF-kappa B在淋巴细胞以及支持细胞（如抗原呈递细胞或上皮细胞）中执行关键的细胞自主功能。我们在本文中讨论的正是NF-kappa B生理影响的这些方面。
This article focuses on the functions of NF-kappa B that vitally impact lymphocytes and thus adaptive immunity. NF-kappa B has long been known to be essential for many of the responses of mature lymphocytes to invading pathogens. In addition, NF-kappa B has important functions in shaping the immune system so it is able to generate adaptive responses to pathogens. In both contexts, NF-kappa B executes critical cell-autonomous functions within lymphocytes as well as within supportive cells, such as antigen-presenting cells or epithelial cells. It is these aspects of NF-kappa B's physiologic impact that we address in this article.