Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases.
Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases.
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DOI：
10.3389/fimmu.2016.00278
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发表时间：
2016
影响因子：
7.3
通讯作者：
Maghazachi AA
中科院分区：
文献类型：
--
作者：
Al-Jaderi Z;Maghazachi AA
几种药物已被批准用于治疗多发性硬化症(MS)。富马酸二甲酯(DMF)是一种口服药物，用于治疗这种疾病，已被证明是有效的，副作用比其他几种药物少。另一方面，富马酸单甲酯(MMF)是一种相关化合物，尽管它有可能成为治疗多发性硬化症和其他疾病的药物，但尚未得到更详细的研究。DMF或MMF的作用机制与其增强抗氧化途径和抑制活性氧有关。然而，也描述了其他机制，包括对单核细胞、树突状细胞、T细胞和自然杀伤细胞的影响。据报道，DMF可能用于治疗牛皮癣、哮喘、侵袭性乳腺癌、造血肿瘤、炎症性肠病、脑出血、骨关节炎、慢性胰腺炎和视网膜缺血。在本文中，我们将涉及其中的一些疾病，重点是DMF和MMF对各种免疫细胞的影响。
Several drugs have been approved for treatment of multiple sclerosis (MS). Dimethyl fumarate (DMF) is utilized as an oral drug to treat this disease and is proven to be potent with less side effects than several other drugs. On the other hand, monomethyl fumarate (MMF), a related compound, has not been examined in greater details although it has the potential as a therapeutic drug for MS and other diseases. The mechanism of action of DMF or MMF is related to their ability to enhance the antioxidant pathways and to inhibit reactive oxygen species. However, other mechanisms have also been described, which include effects on monocytes, dendritic cells, T cells, and natural killer cells. It is also reported that DMF might be useful for treating psoriasis, asthma, aggressive breast cancers, hematopoeitic tumors, inflammatory bowel disease, intracerebral hemorrhage, osteoarthritis, chronic pancreatitis, and retinal ischemia. In this article, we will touch on some of these diseases with an emphasis on the effects of DMF and MMF on various immune cells.