Is having polycystic ovary syndrome a predictor of poor psychological function including anxiety and depression?
Is having polycystic ovary syndrome a predictor of poor psychological function including anxiety and depression?
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DOI：
10.1093/humrep/der071
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发表时间：
2011-06-01
影响因子：
6.1
通讯作者：
Teede, H. J.
中科院分区：
文献类型：
--
作者：
Deeks, A. A.;Gibson-Helm, M. E.;Teede, H. J.
背景：多囊卵巢综合征 (P COS) 的代谢和生殖特征会影响心理功能。我们调查了与消极心理功能相关的因素，以确定它们是否可以预测 PCOS 患者的焦虑和抑郁。 方法：通过问卷调查对 177 名 PCOS 女性（平均 +/- SD 年龄 32.8 +/- 7.8 岁）和 109 名健康对照者（平均年龄 41.9 +/- 15.4 岁）进行横断面研究。主要结果指标是焦虑和抑郁，分别使用医院焦虑抑郁量表 (HADS) 和多维身体自我关系问卷 (MBSRQ) 进行测量。 结果：与对照女性相比，多囊卵巢综合征女性的平均焦虑 HADS 评分较高（9.5 +/- 3.9 对比 6.5 +/- 3.6；P < 0.001），平均抑郁评分较高（5.7 +/- 3.7 对比 3.3） +/- 3.1； < 0.001)，并且在 MBSRQ 的 10 个子量表中，有 7 个子量表的负面身体形象更多。 PCOS 的多变量回归分析显示，自我价值 (P < 0.0001)、健康评估 (P = 0.005)、诊断 PCOS 的时间 (P = 0.003) 和年龄 (P = 0.02) 可以预测焦虑，而对照组女性的焦虑则可以通过自我价值 (P = 0.009)、健康评估 (P = 0.001) 和农村生活 (P = 0.03）。 PCOS 患者抑郁的预测因素包括自我价值 (P = 0.0004)、生活质量 (QOL) (P = 0.004)、健身取向 (P = 0.002)、外观评估 (P = 0.001) 和诊断时间 (P = 0.03)，而没有 PCOS 的女性则通过自我价值 (P < 0.0001)、生活质量 (P < 0.0001)、疾病来预测抑郁。取向（P = 0.001）和外观取向（P = 0.02）。结论：与没有 PCOS 的女性相比，患有 PCOS 的女性焦虑、抑郁和负面身体形象增加。对于患有或不患有 PCOS 的女性，身体形象和自我价值是焦虑和抑郁的预测因素，而生活质量也只能预测抑郁。诊断多囊卵巢综合症所需的时间与心理功能不佳有关。
BACKGROUND: The impact of metabolic and reproductive features of polycystic ovary syndrome (P COS) compromises psychological functioning. We investigated factors associated with negative psychological functioning to determine whether they were predictive of anxiety and depression in PCOS.METHODS: A cross-sectional study was performed by questionnaire in 177 women with PCOS (mean +/- SD age 32.8 +/- 7.8 years) and 109 healthy controls (mean age 41.9 +/- 15.4 years). Main outcome measures were anxiety and depression, measured using the Hospital Anxiety Depression Scale (HADS) and Multidimensional Body-Self Relations Questionnaire (MBSRQ), respectively.RESULTS: Women with PCOS, compared with control women, had a higher mean anxiety HADS score (9.5 +/- 3.9 versus 6.5 +/- 3.6; P < 0.001), a higher mean depression score (5.7 +/- 3.7 versus 3.3 +/- 3.1; P < 0.001) and more negative body image in 7 out of 10 subscales of the MBSRQ. Multivariate regression analysis in PCOS showed that anxiety was predicted by self-worth (P < 0.0001), health evaluation (P = 0.005), time taken to diagnose PCOS (P = 0.003) and age (P = 0.02), while in control women, anxiety was predicted by self-worth (P = 0.009), health evaluation (P = 0.001) and rural living (P = 0.03). Depression in PCOS was predicted by self-worth (P = 0.0004), quality of life (QOL) (P = 0.004), fitness orientation (P = 0.002), appearance evaluation (P = 0.001) and time to diagnosis (P = 0.03) and in women without PCOS, by self-worth (P < 0.0001), QOL (P < 0.0001), illness orientation (P = 0.001) and appearance orientation (P = 0.02).CONCLUSIONS: Women with PCOS have increased anxiety, depression and negative body image compared with women without PCOS. In women with or without PCOS, body image and self-worth are predictors of both anxiety and depression, while QOL also predicts only depression. Time taken to diagnose PCOS is associated with poor psychological functioning.