Exaggerated pressure response to exercise in men at risk for systemic hypertension.
Exaggerated pressure response to exercise in men at risk for systemic hypertension.
复制标题
有全身性高血压风险的男性对运动的压力反应过度。
DOI：
10.1016/0002-9149(90)91139-w
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Lovallo,WR
中科院分区：
文献类型：
--
作者：
Wilson,MF;Sung,BH;Pincomb,GA;Lovallo,WR
血压正常、全身性高血压高风险的人对精神和身体压力源的心血管反应更大。本研究比较了高血压高危人群（父母有高血压史，静息血压正常值高，n= 20）和低血压高危人群（父母无高血压史，血压正常值低，n= 15）血压正常男性（年龄28±0.8岁，平均值±平均值标准误）对运动的心血管反应。所有男性的体重和运动耐量均正常。在分级仰卧自行车运动期间，35%（7/20）的高风险男性出现过度BP反应（≥ 230 100 mm Hg），而低风险男性为0%，因此形成3组（低风险、高风险正常BP反应、高风险过度反应）。用核素心动图测定心功能。分别在安静时和每次运动负荷时测量心脏指数、外周阻力指数、左室射血分数和收缩力指数。使用静息血压或其他心血管变量，无法区分高风险夸大反应者与高风险正常反应者。在运动过程中，所有3组的心输出量增加相等。然而，高风险的夸大反应者外周阻力下降变钝，导致血压过度升高。这一发现表明运动诱导的血管舒张能力受损，表明过度反应组可能是这3组中未来高血压的最高风险。
Normotensive persons at high risk of developing systemic hypertension have greater cardiovascular reactivity to mental and physical stressors. This study compared cardiovascular responses to exercise in normotensive men (aged 28±0.8 years [mean±standard error of the mean]) at high risk (positive parental history and high normal resting blood pressure [BP], n= 20) and at low risk (negative history, low normal BP, n= 15) of hypertension. All men had normal body weight and exercise tolerance. During graded supine bicycle exercise, 35%(7 of 20) of high-risk men had exaggerated BP responses (≥ 230 100 mm Hg) versus 0% of low-risk men, thus forming 3 groups (low risk, high-risk normal BP response, high-risk exaggerated response). Cardiac function was measured by nuclear cardiography. Cardiac index, peripheral resistance index, left ventricular ejection fraction and contractility index were measured at rest and during each exercise work load. High-risk exaggerated responders could not be distinguished from their high-risk normal-responding counterparts using resting BP or other cardiovascular variables. During exercise all 3 groups had equivalent increases in cardiac output. However, the high-risk exaggerated responders had blunting in peripheral resistance decline, resulting in excessive BP increases. This finding suggests an impaired capacity for exercise-induced vasodilation, indicating that the exaggerated response group may be at highest risk for future hypertension in these 3 groups.