Repetition priming effects dissociate between miniature eye movements and induced gamma-band responses in the human electroencephalogram
Repetition priming effects dissociate between miniature eye movements and induced gamma-band responses in the human electroencephalogram
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DOI：
10.1111/ejn.12244
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发表时间：
2013-08-01
影响因子：
3.4
通讯作者：
Gruber, Thomas
中科院分区：
文献类型：
--
作者：
Hassler, Uwe;Friese, Uwe;Gruber, Thomas
诱发γ-波段反应（iGBR）在人类脑电图（EEG）中的作用是一个有争议的话题。一方面，iGBR已经与反映皮质对象表征的（再）激活的神经元活动相关联。另一方面，研究表明，微型扫视（MS）导致EEG中的高频伪影，可以模拟皮质iGBR。我们记录了EEG和眼球运动的同时，参与者进行了联合重复启动和物体识别实验。MS率主要调制对象熟悉的时间窗口从100到300毫秒刺激后发作。相比之下，伪影校正的iGBR在延长的时间窗口中对对象重复和对象熟悉度敏感。EEG源分析显示，刺激重复调制的iGBR在颞叶和枕叶皮层区域，而熟悉与顶枕区的活动。这些结果与采用功能性磁共振成像或脑磁图的神经影像学研究一致。我们的结论是MS反映了早期的视觉感知机制，而iGBR反映了代表感知对象的皮层网络的激活。
The role of induced gamma-band responses (iGBRs) in the human electroencephalogram (EEG) is a controversial topic. On the one hand, iGBRs have been associated with neuronal activity reflecting the (re-) activation of cortical object representations. On the other hand, it was shown that miniature saccades (MSs) lead to high-frequency artifacts in the EEG that can mimic cortical iGBRs. We recorded EEG and eye movements simultaneously while participants were engaged in a combined repetition priming and object recognition experiment. MS rates were mainly modulated by object familiarity in a time window from 100 to 300 ms after stimulus onset. In contrast, artifact-corrected iGBRs were sensitive to object repetition and object familiarity in a prolonged time window. EEG source analyses revealed that stimulus repetitions modulated iGBRs in temporal and occipital cortex regions while familiarity was associated with activity in parieto-occipital regions. These results are in line with neuroimaging studies employing functional magnetic resonance imaging or magnetoencephalography. We conclude that MSs reflect early mechanisms of visual perception while iGBRs mirror the activation of cortical networks representing a perceived object.