Unusual Enantiomeric Resolution Phenomenon Observed upon Recrystallization of a Racemic Compound
Unusual Enantiomeric Resolution Phenomenon Observed upon Recrystallization of a Racemic Compound
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外消旋化合物重结晶时观察到的异常对映体拆分现象
DOI：
10.1002/anie.199623721
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发表时间：
1996
影响因子：
--
通讯作者：
Keiji. Yamamoto
中科院分区：
文献类型：
--
作者：
T. Ushio;R. Tamura;Hiroki Takahashi;N. Azuma;Keiji. Yamamoto
通过简单的重结晶即可实现抗过敏剂 (±)-ST 的有效对映体拆分，显示出晶体多态性。既形成外消旋化合物的稳定晶体，又形成亚稳定混晶，母液对映体富集几乎达到100％ee。
Efficient enantiomeric resolution of the antiallergenic agent (±)‐ST, which shows crystalline polymorphism, is accomplished by simple recrystallization. Both stable crystals of the racemic compound and metastable mixed crystals are formed, and the enantiomeric enrichment of the mother liquor virtually reaches 100% ee.