Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187
Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187
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DOI：
10.1016/j.phytol.2017.09.011
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发表时间：
2017-12-01
影响因子：
1.7
通讯作者：
Shen, Xu
中科院分区：
文献类型：
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作者：
Choochuay, Jutatip;Xu, Xin;Shen, Xu
从土源真菌多孔曲霉（Aspergillus polyporicola）PSU-RSPG 187的发酵液中分离得到两个新的弯孢菌素衍生物：curvulopyran（1）和ent-curvulone A（2），沿着10个已知化合物，包括5个细胞松弛素和5个弯孢菌素。通过波谱方法确定了它们的结构。已知的Aspochalasin D对氟胞嘧啶耐药的新型隐球菌显示出中等的抗真菌活性，MIC值为32 μ g/mL，对非癌细胞系没有细胞毒性活性。此外，已知的α，β-脱氢弯孢菌素对KB和MCF-7细胞系均表现出潜在的细胞毒活性，IC 50值为11.26和19.50 μ M。不幸的是，它对Vero细胞系有很强的活性。
Two new curvularin derivatives, curvulopyran (1) and ent-curvulone A (2), along with ten known compounds including five cytochalasins and five curvularins, were isolated from a culture broth of the soil-derived fungus Aspergillus polyporicola PSU-RSPG187. Their structures were determined by spectroscopic methods. Known aspochalasin D displayed moderate antifungal activity against flucytosine-resistant Cryptococcus neoformans with an MIC value of 32 mu g/mL and showed no cytotoxic activity against noncancerous cell lines. In addition, known alpha, beta-dehydrocurvularin exhibited potential cytotoxic activity against both KB and MCF-7 cell lines with the IC50 values of 11.26 and 19.50 mu M. Unfortunately, it was strongly active against Vero cell lines.