Stereo- and Regioselective Gold-Catalyzed Hydroamination of Internal Alkynes with Dialkylamines
Stereo- and Regioselective Gold-Catalyzed Hydroamination of Internal Alkynes with Dialkylamines
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DOI：
10.1021/ja109192w
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发表时间：
2010-12-29
影响因子：
15
通讯作者：
Stradiotto, Mark
中科院分区：
文献类型：
--
作者：
Hesp, Kevin D.;Stradiotto, Mark
我们报告使用的P，N-配体支持的金络合物作为一个国家的最先进的预催化剂的立体选择性加氢胺化的内部芳基炔与二烷基胺，以提供E-烯胺产品。以胺（醚、硫化物、N-Boc胺、氟、腈、硝基、醇、N-杂环、酰胺、酯和羧酸）和炔（醚、N-杂环、N-邻苯二甲酰亚胺胺和甲硅烷基醚）上的各种官能团为特征的底物具有合成上有用的区域选择性。
We report the use of a P,N-ligand to support a gold complex as a state-of-the-art precatalyst for the stereoselective hydroamination of internal aryl alkynes with dialkylamines to afford E-enamine products. Substrates featuring a diverse range of functional groups on both the amine (ether, sulfide, N-Boc amine, fluoro, nitrile, nitro, alcohol, N-heterocycles, amide, ester, and carboxylic acid) and alkyne (ether, N-heterocycles, N-phthalimide amines, and silyl ethers) are accommodated with synthetically useful regioselectivity.