TRAF-mediated TNFR-family signaling.
TRAF-mediated TNFR-family signaling.
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DOI：
10.1002/0471142735.im1109ds87
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发表时间：
2009-11-01
影响因子：
--
通讯作者：
Choi, Yongwon
中科院分区：
文献类型：
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作者：
Ha, Hyunil;Han, Daehee;Choi, Yongwon
肿瘤坏死因子（TNF）超家族由多种细胞结合和分泌的蛋白质组成，调节许多细胞过程。特别地，TNF家族蛋白调节肿瘤细胞以及活化的免疫细胞的增殖和死亡。本综述讨论了哺乳动物TNF受体相关因子（TRAFs），其中TRAF1，2，3，5和6已被证明直接或间接与TNF受体超家族成员相互作用。TRAF蛋白的结构特征描述沿着与TRAF相互作用的蛋白质和由TRAF蛋白激活的信号通路的讨论。最后，我们研究了在TRAF基因敲除小鼠中观察到的表型。
The tumor necrosis factor (TNF) superfamily consists of a wide variety of cell-bound and secreted proteins that regulate numerous cellular processes. In particular, TNF-family proteins regulate the proliferation and death of tumor cells, as well as activated immune cells. This overview discusses the mammalian TNF receptor-associated factors (TRAFs), of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNF receptor superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF-interacting proteins and the signaling pathways activated by the TRAF proteins. Finally, we examine the phenotypes observed in TRAF-knockout mice.