Pharmacokinetics of diltiazem after intravenous and oral administration
Pharmacokinetics of diltiazem after intravenous and oral administration
复制标题
地尔硫卓静脉和口服给药后的药代动力学
DOI：
10.1007/bf00610053
复制
发表时间：
2004
影响因子：
2.9
通讯作者：
P. Morselli
中科院分区：
文献类型：
--
作者：
P. Hermann;S. Rodger;G. Remones;J. Thénot;D. London;P. Morselli
研究了新型钙拮抗剂地尔硫卓在12名志愿者口服(60 Mg)和静脉(15 Mg)给药后的药动学特征。静脉注射后。结果表明，地尔硫卓存在双相消除，分布半衰期为0.3±0.2h，消除半衰期为3.1±1.0h，表观分布体积为5.3±1.71/kg，总清除量为1.28±0.48 L/kg/h，口服后消除相半衰期为3.2±1.3h，绝对生物利用度为24~74%(平均42±18%)。个体间的差异可以用可变的首过效应来解释。
SummaryThe kinetic profile of diltiazem, a novel calcium antagonist, was studied in 12 volunteers following oral (60 mg) and intravenous (15 mg) administration. After i.v. administration biphasic elimination was observed, with a distribution half-life of 0.3±0.2 h and an elimination half-life of 3.1±1.0 h; the apparent volume of distribution was 5.3±1.71/kg and the total clearance was 1.28±0.48 l/kg/h. After the oral dose the elimination phase had a half-life of 3.2±1.3 h. The absolute bioavailability of diltiazem ranged from 24 to 74% (mean 42±18%). The interindividual variation may be explained by a variable first pass effect.
地尔硫卓对心肌血流量的影响。
影响因子：
37.8
作者：
Bache,RJ;Dymek,DJ
通讯作者：
Dymek,DJ