Tupaia belangeri as an experimental animal model for viral infection.
Tupaia belangeri as an experimental animal model for viral infection.
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DOI：
10.1538/expanim.63.367
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发表时间：
2014
影响因子：
2.4
通讯作者：
Kohara M
中科院分区：
文献类型：
--
作者：
Tsukiyama-Kohara K;Kohara M
图派是一种小型哺乳动物，外形与松鼠相似。该群体的形态和行为特征已被广泛描述，尽管以前被归类为灵长类动物，但最近的研究已将该群体归入其自己的家族--图派科。基因组分析显示，与啮齿动物相比，图帕亚属更接近人类。此外，图帕亚人对乙肝病毒和丙型肝炎病毒很敏感。另一种已被证明对这两种病毒都敏感的实验动物是黑猩猩，但对动物实验的限制意味着，用黑猩猩进行实验几乎是不可能的。因此，作为动物感染模型的图帕亚的开发可能成为肝炎病毒研究和药物开发的临床前研究的有力工具。
Tupaias, or tree shrews, are small mammals that are similar in appearance to squirrels. The morphological and behavioral characteristics of the group have been extensively characterized, and despite previously being classified as primates, recent studies have placed the group in its own family, the Tupaiidae. Genomic analysis has revealed that the genus Tupaia is closer to humans than it is to rodents. In addition, tupaias are susceptible to hepatitis B virus and hepatitis C virus. The only other experimental animal that has been demonstrated to be sensitive to both of these viruses is the chimpanzee, but restrictions on animal testing have meant that experiments using chimpanzees have become almost impossible. Consequently, the development of the tupaia for use as an animal infection model could become a powerful tool for hepatitis virus research and in preclinical studies on drug development.