Preparation of spherical calcium phosphate granulates suitable for the biofunctionalization of active brazed titanium alloy coatings
Preparation of spherical calcium phosphate granulates suitable for the biofunctionalization of active brazed titanium alloy coatings
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DOI：
10.1515/bmt-2014-0017
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发表时间：
2015-04
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影响因子：
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通讯作者：
Karolina Schickle;Jose L. Gerardo-Nava;S. Puidokas;Sharareh Samadian Anavar;Christian Bergmann;P. Gingter;B. Schickle;K. Bobzin;H. Fischer
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文献类型：
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作者：
Karolina Schickle;Jose L. Gerardo-Nava;S. Puidokas;Sharareh Samadian Anavar;Christian Bergmann;P. Gingter;B. Schickle;K. Bobzin;H. Fischer
摘要 钛基合金可以主动钎焊到生物惰性陶瓷上，并有可能用作生物相容性涂层。为了进一步提高其体内生物活性，可以在其表面层引入基于磷酸钙（CaP）的颗粒。为此，机械稳定的 CaP 基颗粒需要能够承受钎焊工艺的要求。在这项研究中，通过喷雾干燥制造了由磷酸钙复合材料制成的球形颗粒，该复合材料主要由β-磷酸三钙和羟基磷灰石、生物活性玻璃以及前两者的混合物组成。研究了浆料中有机添加剂（Dolapix CE64、柠檬酸三钠）和固体含量（30-80 wt%）对颗粒物理特性的影响。进行了X射线衍射、Brunauer、Emmett、Teller比表面积标准法、扫描电子显微镜、粒度分析和单颗粒强度。我们的结果表明，柠檬酸三钠可以生产具有规则形态、高密度和增加的失效应力值的颗粒。坚固的颗粒也能承受钎焊过程。这些结果表明，CaP 生物活性剂可以在要求苛刻的冶金过程中生成并整合，从而实现金属钎料的一步生物活化。
Abstract Titanium-based alloys can be actively brazed onto bio-inert ceramics and potentially be used as biocompatible coatings. To further improve their bioactivity in vivo, introduction of calcium phosphate (CaP)-based granulates onto their surface layer is possible. For this, mechanically stable CaP-based granulates need to be able to withstand the demand of the brazing process. In this study, spherical granulates, made of a calcium phosphate composite composed primarily of β-tricalcium phosphate and hydroxyapatite, a bioactive glass, and a mixture of the previous two, were manufactured by spray drying. The influence of organic additives (Dolapix CE64, trisodium citrate) and solids content (30–80 wt%) in the slurry on the physical characteristics of granulates was investigated. X-ray diffraction, Brunauer, Emmett, Teller specific surface area standard method, scanning electron microscopy, granulate size analysis, and single granule strength were performed. Our results showed that trisodium citrate permitted the production of granulates with regular morphology, high density, and increased failure stress values. The strong granules also withstood the brazing process. These results show that CaP bioactive agents can be generated and be integrated during the demanding metallurgical processes, allowing for one-step bioactivation of metal brazes.