Transcriptional regulation of chemokine expression in ovarian cancer.
Transcriptional regulation of chemokine expression in ovarian cancer.
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DOI：
10.3390/biom5010223
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发表时间：
2015-03-17
期刊：
影响因子：
5.5
通讯作者：
Vancurova I
中科院分区：
文献类型：
--
作者：
Singha B;Gatla HR;Vancurova I
促炎和促血管生成趋化因子的表达增加通过诱导肿瘤细胞增殖、存活、血管生成和转移来促进卵巢癌的进展。这些趋化因子促进卵巢癌进展和转移的巨大潜力强调了对其严格转录调控的必要性。在这篇综述中，我们重点介绍了在卵巢癌细胞中调节促炎趋化因子转录的关键机制，并在控制卵巢癌进展中发挥重要作用。我们进一步讨论了趋化因子在耐药性中表达增加的潜在机制，以及我们对未来研究的看法。
The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis of ovarian cancer underscores the need for their stringent transcriptional regulation. In this Review, we highlight the key mechanisms that regulate the transcription of pro-inflammatory chemokines in ovarian cancer cells, and that have important roles in controlling ovarian cancer progression. We further discuss the potential mechanisms underlying the increased chemokine expression in drug resistance, along with our perspective for future studies.