C-reactive protein concentration predicts mortality in type 2 diabetes: the Diabetes Heart Study.
C-reactive protein concentration predicts mortality in type 2 diabetes: the Diabetes Heart Study.
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DOI：
10.1111/j.1464-5491.2011.03560.x
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Bowden DW
中科院分区：
文献类型：
--
作者：
Cox AJ;Agarwal S;M Herrington D;Carr JJ;Freedman BI;Bowden DW
尽管目前美国心脏协会的指南解决了C反应蛋白浓度和心血管疾病风险，但仍不清楚这种模式是否在不同疾病负担的人群中一致。患有2型糖尿病的个体代表了心血管疾病和随后死亡率风险增加的一个群体。本研究旨在研究糖尿病心脏研究中2型糖尿病患者的C反应蛋白浓度与全因死亡风险之间的关系。共有846名2型糖尿病患者和C反应蛋白基线测量的欧洲裔美国人进行了评估。在7.3 ± 2.1年（平均值±标准差）的随访期后确定生命状态。比较了存活和死亡亚组之间的C反应蛋白浓度沿着其他已知的心血管疾病风险因素，包括血脂。进行逻辑回归以确定与C反应蛋白浓度增加相关的死亡风险。随访时，160人（18.7%）死亡。未观察到存活和死亡亚组之间基线血糖或血脂指标的显著差异。死亡亚组的基线C反应蛋白浓度（9.37 ± 15.94）显著高于存活亚组（5.36 ± 7.91 mg/l; P < 0.0001）。C反应蛋白浓度为3-10 mg/l的参与者在随访时死亡的可能性约为2倍（OR 2.06; 95% CI 1.17-3.62）; C反应蛋白>10 mg/l的参与者死亡的可能性超过5倍（OR 5.24; CI 2.80-9.38）。本研究记录了C-反应蛋白在预测欧洲裔美国人2型糖尿病全因死亡风险中的效用，并支持其作为风险预测模型中的筛选工具。
Although current American Heart Association guidelines address C-reactive protein concentration and cardiovascular disease risk, it remains unclear whether this paradigm is consistent across populations with differing disease burdens. Individuals with Type 2 diabetes mellitus represent one group at increased risk of cardiovascular disease and subsequent mortality. This study aimed to examine the relationship between C-reactive protein concentrations and risk for all-cause mortality in European Americans with Type 2 diabetes from the Diabetes Heart Study. A total of 846 European Americans with Type 2 diabetes and baseline measures of C-reactive protein were evaluated. Vital status was determined after a follow-up period of 7.3 ± 2.1 years (mean ± SD). C-reactive protein concentrations were compared between living and deceased subgroups along with other known risk factors for cardiovascular disease, including blood lipids. Logistic regression was performed to determine risk for mortality associated with increasing C-reactive protein concentrations. At follow-up 160 individuals (18.7%) were deceased. No significant differences in baseline serum glucose or lipid measures were observed between living and deceased subgroups. Baseline C-reactive protein concentrations were significantly higher in the deceased subgroup (9.37 ± 15.94) compared with the living subgroup (5.36 ± 7.91 mg/l; P < 0.0001). Participants with C-reactive protein concentrations of 3–10 mg/l were approximately two times more likely to be deceased at follow-up (OR 2.06; 95% CI 1.17–3.62); those with C-reactive protein >10 mg/l were more than five times more likely to be deceased (OR 5.24; CI 2.80–9.38). This study documents the utility of C-reactive protein in predicting risk for all-cause mortality in European Americans with Type 2 diabetes and supports its use as a screening tool in risk prediction models.
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影响因子：
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