Machine Perfusion Decreases Delayed Graft Function in Donor Grafts With High Kidney Donor Profile Index
Machine Perfusion Decreases Delayed Graft Function in Donor Grafts With High Kidney Donor Profile Index
复制标题
DOI：
10.6002/ect.2019.0139
复制
发表时间：
2021-01-01
影响因子：
0.9
通讯作者：
Reyes, Jorge D.
中科院分区：
文献类型：
--
作者：
Montenovo, Martin, I;Perkins, James D.;Reyes, Jorge D.
目的：肾移植是治疗终末期肾病的最佳方法。使用机器灌注对具有不同肾脏供体特征指数评分的供体肾脏的影响尚不清楚。我们试图评估机器灌注对延迟移植肾功能发生率的影响，在不同评分组的肾移植肾供体配置文件Index.Materials和方法：我们进行了回顾性分析，从2008年1月至2017年9月的成年受者（>= 18岁）接受肾脏移植从死亡供体。所有移植受者都被随访至2017年12月。接受多器官移植或活体供肾的受者被排除在我们的分析之外。根据肾供体概况指数评分的5个供体类别（0-20、21-40、41-60、61-80和81-100）对受体进行分类。Logistic回归分析进行了每个评分组，以确定机器灌注对每个评分group.Results内的延迟移植功能的发展的影响：我们的研究包括101 222名受者符合纳入标准。多变量分析显示，机器灌注仅在高风险供体中与移植物功能延迟发展显著降低相关：61 - 80分组（比值比= 0.83;置信区间，0.78-0.89）和81至100分组结论：机器灌注仅在风险较高的供肾中有利于减少移植肾功能延迟恢复。
Objectives: Kidney transplant is the optimal treatment for patients with end-stage renal disease. The effects of using machine perfusion for donor kidneys with varying Kidney Donor Profile Index scores are unknown. We sought to assess the impact of machine perfusion on the incidence of delayed graft function in different score groups of kidney grafts classified with the Kidney Donor Profile Index.Materials and Methods: We conducted a retrospective analysis from January 2008 through September 2017 of adult recipients (>= 18 years old) undergoing kidney-only transplant from deceased donors. All transplant recipients were followed until December 2017. Recipients who received multiorgan transplants or kidneys from living donors were excluded from our analyses. Recipients were divided according to 5 donor categories of Kidney Donor Profile Index scores (0-20, 21-40, 41-60, 61-80, and 81-100). Logistic regression analysis was performed for each score group to determine the effects of machine perfusion on development of delayed graft function within each score group.Results: Our study included 101 222 recipients who met the inclusion criteria. Multivariate analysis revealed that machine perfusion was associated with significantly decreased development of delayed graft function only in donors with high-risk profiles: the 61 to 80 score group (odds ratio = 0.83; confidence interval, 0.78-0.89) and the 81 to 100 score group (odds ratio = 0.72; confidence interval, 0.67-0.78).Conclusions: Machine perfusion is beneficial in reducing delayed graft function only in donor kidneys with a higher risk profile.