The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents.
The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents.
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DOI：
10.3389/fendo.2022.976998
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发表时间：
2022
影响因子：
5.2
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中科院分区：
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了解不同体成分儿童青少年高血糖和血脂异常的患病率，探讨体成分指标尤其是肌肉质量与儿童青少年糖脂代谢的关系。这项全国性的横断面研究包括8,905名6至18岁的儿童和青少年。所有受试者均接受双能X线吸收法测定血糖和血脂（包括TC、TG、LDL-C和HDL-C）。采用混合模型、层次分析和分段回归等方法研究了体成分指标尤其是肌肉质量对糖脂代谢的影响。高总胆固醇（TC）和高甘油三酯（22.3%和6.6%）的患病率最高的男孩和女孩的高肌肉质量和高脂肪质量，高肌肉质量和高脂肪质量的女孩也有最高的高血糖症（7.1%）的患病率。在脂肪分层后，较高的肌肉质量与较低的高血糖几率相关（OR = 0.62; 95%CI：0.46，0.84; P = 0.002），肌肉质量与TC呈负相关（β = −0.07; 95%CI：-0.12，-0.03; P < 0.001）在脂肪量正常的男孩中，而高脂肪组高肌肉量与高血糖和TC无显著相关性（P = 0.368和0.372）。高肌肉和高脂肪量的身体组成表型具有最高的血脂异常患病率。在只有正常脂肪量的个体中，较高的肌肉质量与较低的高血糖风险和TC水平相关。
To evaluate the prevalence of hyperglycemia and dyslipidemia among different body composition and investigate the associations of body composition indicators, especially the muscle mass, with glucose and lipids metabolism in children and adolescents. This nationwide cross-sectional study included 8,905 children and adolescents aged 6 to 18 years. All participants underwent dual-energy x-ray absorptiometry and their blood-concentrated glucose and lipids (including TC, TG, LDL-C and HDL-c) were measured. Mixed model, hierarchical analysis, and piecewise regression were used to study the effect of body composition indicators, especially the muscle mass, on glucose and lipids metabolism. The greatest prevalence of high total cholesterol (TC, 6.9% and 6.9%) and high triglyceride (22.3% and 6.6%) was found in both boys and girls with high muscle mass and high fat mass, and girls with high muscle mass and high fat mass also had the highest prevalence of hyperglycemia (7.1%). After fat stratification, higher muscle mass was associated with lower odds of hyperglycemia (OR = 0.62; 95%CI: 0.46,0.84; P = 0.002) and muscle mass was inversely associated with TC (β = −0.07; 95%CI: -0.12,-0.03; P < 0.001) in boys with normal fat mass, but high muscle mass was not significantly associated with hyperglycemia and TC in high-fat-mass group (P = 0.368 and 0.372). The body composition phenotype of high muscle and high fat mass have the highest prevalence of dysglycemia and dyslipidemia. Higher muscle mass was associated with a lower risk of hyperglycemia and TC levels in individuals only with normal fat mass.