PATHOLOGICAL CORRELATES OF INCIDENTAL MRI WHITE-MATTER SIGNAL HYPERINTENSITIES
PATHOLOGICAL CORRELATES OF INCIDENTAL MRI WHITE-MATTER SIGNAL HYPERINTENSITIES
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DOI：
10.1212/wnl.43.9.1683
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发表时间：
1993-09-01
期刊：
影响因子：
9.9
通讯作者：
LECHNER, H
中科院分区：
文献类型：
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作者：
FAZEKAS, F;KLEINERT, R;LECHNER, H
我们将11例老年患者（年龄范围52 ~ 82岁）MRI上偶发性白色信号高信号相关的组织病理学改变与此类异常的描述性分类相关联。点状、早期融合和融合白色物质高信号对应于缺血性组织损伤的严重程度增加，范围从轻度血管周围改变到大面积纤维丢失、多个小空洞和显著小动脉硬化。小囊性梗死和斑片状髓鞘稀疏也是不规则脑室周围高信号的特征。然而，高信号室周帽和平滑晕是非缺血性起源，构成了与室管膜下胶质增生和室管膜衬里不连续相关的脱髓鞘区域。基于这些发现，我们的分类似乎反映了偶然MRI信号异常的不同病因和严重程度，如果将其修改为同时治疗不规则脑室周围和融合的深部白色高信号。
We related the histopathologic changes associated with incidental white matter signal hyperintensities on MRIs from 11 elderly patients (age range, 52 to 82 years) to a descriptive classification for such abnormalities. Punctate, early confluent, and confluent white matter hyperintensities corresponded to increasing severity of ischemic tissue damage, ranging from mild perivascular alterations to large areas with variable loss of fibers, multiple small cavitations, and marked arteriolosclerosis. Microcystic infarcts and patchy rarefaction of myelin were also characteristic for irregular periventricular high signal intensity. Hyperintense periventricular caps and a smooth halo, however, were of nonischemic origin and constituted areas of demyelination associated with subependymal gliosis and discontinuity of the ependymal lining. Based on these findings, our classification appears to reflect both the different etiologies and severities of incidental MRI signal abnormalities, if it is modified to treat irregular periventricular and confluent deep white matter hyperintensities together.