Metabolic abnormalities and body composition of HIV-infected children on Lopinavir or Nevirapine-based antiretroviral therapy
Metabolic abnormalities and body composition of HIV-infected children on Lopinavir or Nevirapine-based antiretroviral therapy
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DOI：
10.1136/archdischild-2012-302633
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发表时间：
2013-04-01
影响因子：
5.2
通讯作者：
Kuhn, Louise
中科院分区：
文献类型：
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作者：
Arpadi, Stephen;Shiau, Stephanie;Kuhn, Louise
背景：很少有研究评估接受抗逆转录病毒治疗（ART）的围产期HIV感染非洲儿童的代谢和身体成分改变。我们比较了利托那韦增强的洛匹那韦对儿童代谢谱和局部脂肪的影响方法本研究评估了156名完成随机试验的HIV感染儿童的代谢和身体组成结果，该试验评估了在约翰内斯堡继续使用基于洛匹那韦/利托那韦的ART或转换为基于奈韦拉平的ART，南非（2005-2010年）。测定空腹总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、总甘油三酯和局部体脂（BF）。结果156名儿童（平均年龄5.1PLUSMN;0.8岁，平均治疗持续时间4.2PLUSMN;0.7年，平均时间自随机化3.4PLUSMN;0.7年）入组。85例随机分配至洛匹那韦/利托那韦组，71例随机分配至奈韦拉平组。洛匹那韦/利托那韦组的平均HDL较低（1.3PLUSMN;0.4 vs 1.5PLUSMN;0.4 mmol/l，p
Background Few studies have assessed metabolic and body composition alterations in perinatally HIV-infected African children on antiretroviral therapy (ART). We compared metabolic profiles and regional fat of children on ritonavir-boosted lopinavir (lopinavir/ritonavir), lamivudine and stavudine to those switched to nevirapine, lamivudine and stavudine.Methods This study evaluated metabolic and body composition outcomes in 156 HIV-infected children completing a randomised trial that assessed the continued use of lopinavir/ritonavir-based ART or switch to nevirapine-based ART in Johannesburg, South Africa (2005-2010). Fasting total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides total and regional body fat (BF) were measured. A clinical assessment for lipodystrophy (LD) was conducted.Results 156 children (mean age 5.1PLUSMN;0.8 years, mean duration of treatment 4.2PLUSMN;0.7 years, mean time since randomisation 3.4PLUSMN;0.7 years) were enrolled. 85 were randomised to the lopinavir/ritonavir group and 71 to the nevirapine group. The lopinavir/ritonavir group had lower mean HDL (1.3PLUSMN;0.4 vs 1.5 & PLUSMN;0.4 mmol/l, p