Pulsatile patterns of gonadotropin release in subjects with and without ovarian function.
Pulsatile patterns of gonadotropin release in subjects with and without ovarian function.
复制标题
有或没有卵巢功能的受试者促性腺激素释放的脉动模式。
DOI：
10.1210/jcem-34-4-671
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
L. Ajabor
中科院分区：
文献类型：
--
作者：
S. Yen;C. Tsai;F. Naftolin;G. Vandenberg;L. Ajabor
绝经前和绝经后妇女的血清黄体生成素和卵泡刺激素浓度每分钟的波动都类似于脉动型。在月经周期中，黄体生成素呈脉动型，而卵泡刺激素未见。卵泡早期、黄体早期和周期中期高峰的周期为1-2小时，黄体中期和黄体晚期的周期为4小时。在卵泡晚期，仅观察到“轻微的振荡”。循环黄体生成素的净增加在周期中期的脉搏中被发现，是周期中其他阶段的两倍多。相比之下，绝经后的受试者有两种促性腺激素的脉搏。这些通常是一致的，然而，在黄体生成素和卵泡刺激素模式之间有轻微的不同步是明显的。绝经后受试者的脉搏频率与卵泡期和MIDC相同。
Minute-to-minute fluctuations of serum LH and FSH concentrations resembling a pulsatile pattern were demonstrated in both pre- and post-menopausal women. A pulsatile pattern of LH but not FSH was seen during the menstrual cycle. These appear to follow a varying frequency and magnitude according to the different phases of the cycle; a periodicity of 1–2 hr was seen during the early follicular phase, early luteal phase and midcycle surge while a periodicity of 4 hr was seen in the mid- and late-luteal phase. During the late follicular phase only “minor oscillations” were noted. A greater net increase of circulating LH was found in pulses during the midcycle surge which was more than double that seen during other phases of the cycle. In contrast, post-menopausal subjects had pulses of both gonadotropins. These were usually coincident, however, a minor asynchrony between LH and FSH patterns was discernible. The frequency of pulses in the postmenopausal subjects was the same as in the follicular phase and midc...