THE EFFECTS OF FRONTAL-CORTEX LESIONS ON EVENT-RELATED POTENTIALS DURING AUDITORY SELECTIVE ATTENTION
THE EFFECTS OF FRONTAL-CORTEX LESIONS ON EVENT-RELATED POTENTIALS DURING AUDITORY SELECTIVE ATTENTION
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DOI：
10.1016/0013-4694(81)91431-0
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
NEVILLE, HJ
中科院分区：
文献类型：
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作者：
KNIGHT, RT;HILLYARD, SA;NEVILLE, HJ
比较对照组和单侧额叶背外侧病变患者的听觉选择注意电生理指标。在对照组，注意音后的事件相关电位在刺激后80-500ms表现出增强的负性，其地形图分布与N120不同。额叶的损伤减少了与注意力相关的负性反应，并损害了行为表现。事件相关电位的减少与放置在受损和完整皮质上的电极的记录相同。在刺激传递的耳朵功能方面，左额叶组和右额叶组之间存在差异。左额叶病变的患者在双耳出现音调后注意力减少。右额叶病变患者对右耳音调表现出完整的注意效应，但对左耳音调没有注意相关的负性效应。当左右额叶组被放在一起考虑时，被忽略的通道中的音调在呈现给受损皮质对侧的耳朵时会产生更大的反应。强调额叶在选择性注意过程中的重要作用。尽管在选择性注意任务中产生的内源性负性似乎不是起源于额叶背外侧，但额叶对其表现出调制影响。内源性注意相关负性成分和外源性N120成分明显来自不同的神经生成器。
Electrophysiological indices of auditory selective attention were compared in control subjects and in patients with unilateral lesions of the dorsolateral frontal lobes. In control subjects, ERP following attended tones showed an enhanced negativity from 80-500 ms post-stimulus which had a different topographic distribution than the N120. Lesions of the frontal lobes reduced the attention-related negativity and impaired behavioral performance. The ERP reductions were equivalent in recordings obtained from electrodes placed over the damaged and intact cortex. A difference was noted between left and right frontal groups as an ear function of stimuli delivery. Patients with left frontal lesions showed reduced attention effects following tones presented to either ear. Patients with right frontal lesions showed intact attention effects to right ear tones, but no attention-related negativity to left ear tones. When the left and right frontal groups were considered together, tones in ignored channels produced larger responses when presented to the ear contralateral to damaged cortex. The important role of the frontal lobes in processes of selective attention is stressed. Although the endogenous negativity produced in selective attention tasks does not appear to originate in dorsolateral frontal cortex, the frontal lobes exhibit a modulating influence upon it. The endogenous attention related negativity and exogenous N120 components apparently arise from different neural generators.