Pregnancy enables antibody protection against intracellular infection.
Pregnancy enables antibody protection against intracellular infection.
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DOI：
10.1038/s41586-022-04816-9
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发表时间：
2022-06
期刊：
影响因子：
64.8
通讯作者：
中科院分区：
文献类型：
--
作者：
适应性免疫成分被认为在抗微生物宿主防御中发挥非重叠作用，抗体靶向细胞外环境中的病原体，T细胞消除细胞内的感染。从母亲到婴儿的垂直转移免疫对抗体的依赖可能解释新生儿对细胞内感染的易感性。在这里，我们表明妊娠诱导的翻译后抗体修饰能够保护对典型的细胞内病原体单核细胞增生李斯特菌（Lm）。感染易感性被推翻的新生小鼠出生preconceptually引发的母亲拥有LM特异性IgG或被动转移的抗体从引发怀孕，但不是处女，小鼠。虽然母体B细胞对于产生介导垂直转移保护的IgG是必不可少的，但是它们对于保护功能的抗体获得是必需的，这反而需要唾液酸乙酰酯酶（SIAE）来使IgG可变区N-连接聚糖上的末端唾液酸残基脱乙酰基。脱乙酰Lm特异性IgG通过唾液酸受体CD 22保护新生儿，其抑制B细胞IL-10的产生以释放抗体介导的保护。考虑母胎二分体作为一个联合的免疫单位，揭示了新发现的抗体对细胞内感染的保护作用和微调适应，以增强宿主在怀孕期间和生命早期的防御。
Adaptive immune components are thought to exert nonoverlapping roles in antimicrobial host defense, with antibodies targeting pathogens in the extracellular environment and T cells eliminating infection inside cells. Reliance on antibodies for vertically transferred immunity from mothers to babies may explain neonatal susceptibility to intracellular infections. Here we show pregnancy-induced post-translational antibody modification enables protection against the prototypical intracellular pathogen Listeria monocytogenes (Lm). Infection susceptibility was overturned in neonatal mice born to preconceptually primed mothers possessing Lm-specific IgG or upon passive transfer of antibodies from primed pregnant, but not virgin, mice. While maternal B cells were essential for producing IgG that mediate vertically transferred protection, they were dispensable for antibody acquisition of protective function, which instead required sialic acid acetyl esterase (SIAE) to deacetylate terminal sialic acid residues on IgG variable region N-linked glycans. Deacetylated Lm-specific IgG protected neonates via the sialic acid receptor CD22, which suppressed B cell IL-10 production to unleash antibody-mediated protection. Consideration of the maternal-fetal dyad as a joined immunological unit unveils newfound protective roles for antibodies against intracellular infection and fine-tuned adaptations to enhance host defense during pregnancy and early life.
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影响因子：
8.8
作者：
Langereis MA;Bakkers MJ;Deng L;Padler-Karavani V;Vervoort SJ;Hulswit RJ;van Vliet AL;Gerwig GJ;de Poot SA;Boot W;van Ederen AM;Heesters BA;van der Loos CM;van Kuppeveld FJ;Yu H;Huizinga EG;Chen X;Varki A;Kamerling JP;de Groot RJ
通讯作者：
de Groot RJ
DOI：
10.4049/jimmunol.1201427
发表时间：
2013-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Horikawa M;Weimer ET;DiLillo DJ;Venturi GM;Spolski R;Leonard WJ;Heise MT;Tedder TF
通讯作者：
Tedder TF
影响因子：
16.6
作者：
Hafner L;Pichon M;Burucoa C;Nusser SHA;Moura A;Garcia-Garcera M;Lecuit M
通讯作者：
Lecuit M
影响因子：
64.8
作者：
Elahi, Shokrollah;Ertelt, James M.;Kinder, Jeremy M.;Jiang, Tony T.;Zhang, Xuzhe;Xin, Lijun;Chaturvedi, Vandana;Strong, Beverly S.;Qualls, Joseph E.;Steinbrecher, Kris A.;Kalfa, Theodosia A.;Shaaban, Aimen F.;Way, Sing Sing
通讯作者：
Way, Sing Sing
DOI：
10.1073/pnas.95.8.4504
发表时间：
1998-04-14
影响因子：
11.1
作者：
Hennet, T;Chui, D;Marth, JD
通讯作者：
Marth, JD