Caloric restriction: implications for human cardiometabolic health.
Caloric restriction: implications for human cardiometabolic health.
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热量限制：对人类心脏代谢健康的影响。
DOI：
10.1097/hcr.0b013e318295019e
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发表时间：
2013-07
影响因子：
3.8
通讯作者：
Kraus WE
中科院分区：
文献类型：
--
作者：
Bales CW;Kraus WE
虽然热量限制对人类健康的影响尚未完全了解，但有强有力的证据支持进一步研究其对心血管健康的影响。本综述的目的是通过检查有关热量限制对衰老和心血管健康影响的相关文献来更新科学现状，并讨论热量限制在保护人类心血管功能方面的可能作用。在本综述中，我们将热量限制定义为将能量摄入量减少至远低于随意摄入的热量（人类≥ 10%，动物≥20%）。我们研究了热量限制对长寿和心血管健康影响的相关文献，重点是关于人类热量限制的科学状况。我们强调了减少能量摄入长期影响综合评估（CALERIE）试验的初步和预期结果的重要性。来自动物研究和有限数量的人体试验的证据表明，热量限制有可能通过对血压，脂质，炎症过程和潜在的其他机制的有益影响来延缓心脏衰老并帮助预防动脉粥样硬化性心血管疾病。基于其对心脏代谢健康的已知益处，在综合生活方式计划中包括适度的卡路里限制可能会改善超重和肥胖个体的心脏健康并预防随后的心血管事件。还需要进一步的研究来进一步阐明其对老年人和患有显著合并症（如心力衰竭）的患者的长期适用性。
While the impact of caloric restriction on human health is not fully understood, there is strong evidence to support further studies of its influence on cardiovascular health. The purpose of this review is to update the state of the science by examining the relevant literature regarding calorie restriction effects on aging and cardiovascular health and to discuss the possible role(s) of calorie restriction in preserving cardiovascular function in humans. For purpose of this review, we have defined calorie restriction as a reduction in energy intake well below the amount of calories that would be consumed ad libitum (≥ 10% in humans, ≥20% in animals). We examined the relevant literature on calorie restriction effects on longevity and cardiovascular health, with an emphasis on the state of the science regarding calorie restriction in humans. We have emphasized the importance of the preliminary and expected findings from the Comprehensive Assessment of the Long-term Effect of Reducing Intake of Energy (CALERIE) trial. Evidence from animal studies and a limited number of human trials indicates that calorie restriction has the potential to both delay cardiac aging and help prevent atherosclerotic cardiovascular disease via beneficial effects on blood pressure, lipids, inflammatory processes, and potentially other mechanisms. Based upon its known benefits to cardiometabolic health, including modest calorie restriction in a combined lifestyle program is likely to improve heart health and prevent subsequent cardiovascular events in overweight and obese individuals. Additional study is needed to further illuminate its long-term applicability for older adults and for those with significant comorbidities such as heart failure.