Photosensitizer-conjugated redox-responsive dextran theranostic nanoparticles for near-infrared cancer imaging and photodynamic therapy
Photosensitizer-conjugated redox-responsive dextran theranostic nanoparticles for near-infrared cancer imaging and photodynamic therapy
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DOI：
10.1039/c3py01173a
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发表时间：
2014-02-07
影响因子：
4.6
通讯作者：
Cai, Lintao
中科院分区：
文献类型：
--
作者：
Liu, Peng;Yue, Caixia;Cai, Lintao
光动力疗法（PDT）已成为一种有效的肿瘤治疗方法，对邻近健康组织的非特异性损伤最小。在此，开发了用于肿瘤成像和光动力治疗的氧化还原响应自猝灭多糖治疗纳米颗粒（DEX-SS-Ce6 NP）。右旋糖酐-二氢卟酚e6缀合物（DEX-SS-Ce6）可以在水溶液中自组装成均匀球形的纳米颗粒，并表现出细胞氧化还原响应的荧光信号“关闭/开启”行为。此外，DEX-SS-Ce6 NPs 在近红外（NIR）激光照射下表现出有效的细胞摄取特性和高光毒性。更重要的是，与游离 Ce6 处理的小鼠相比，DEX-SS-Ce6 NP 处理的小鼠在体内研究中表现出增强的肿瘤靶向能力和提高的光动力治疗效率。这些结果表明 DEX-SS-Ce6 NP 是肿瘤成像和光动力治疗的一个巨大潜力系统。
Photodynamic therapy (PDT) has emerged as an effective treatment for tumor with minimal nonspecific damage to adjacent healthy tissues. Herein, redox-responsive self-quenching polysaccharide-based theranostic nanoparticles (DEX-SS-Ce6 NPs) were developed for tumor imaging and photodynamic therapy. The dextran-chlorin e6 conjugates (DEX-SS-Ce6) could self-assemble into nanoparticles with uniform sphere shape in aqueous solution and exhibit cellular redox-responsive "OFF/ON" behavior of a fluorescence signal. In addition, the DEX-SS-Ce6 NPs demonstrated an effective cellular uptake property and high phototoxicity upon near-infrared (NIR) laser irradiation. More importantly, DEX-SS-Ce6 NP treated mice presented enhanced tumor targeting ability and improved photodynamic therapeutic efficiency in an in vivo study, compared with free Ce6 treated mice. These results suggest that the DEX-SS-Ce6 NP is a great potential system for tumor imaging and photodynamic therapy.