Risk Factors and Molecular Epidemiology of Complicated Intra-Abdominal Infections With Carbapenem-Resistant Enterobacteriaceae: A Multicenter Study in China
Risk Factors and Molecular Epidemiology of Complicated Intra-Abdominal Infections With Carbapenem-Resistant Enterobacteriaceae: A Multicenter Study in China
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耐碳青霉烯类肠杆菌科复杂腹腔内感染的危险因素和分子流行病学：中国多中心研究
DOI：
10.1093/infdis/jiz574
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发表时间：
2020-04-01
影响因子：
6.4
通讯作者：
Chen, Dechang
中科院分区：
文献类型：
--
作者：
Liu, Jiao;Zhang, Lidi;Chen, Dechang
背景耐碳青霉烯类肠杆菌科（CRE）感染与患者预后不良相关。中国复杂性腹腔内感染（cIAI）中CRE的危险因素和分子流行病学数据有限。本研究基于碳青霉烯类耐药机制探讨了cIAI伴CRE的危险因素和相关死亡率。在这项回顾性分析中，我们确定了2013年1月1日至2018年10月31日在中国14个重症监护室住院的1024例cIAI患者。对30株CRE分离株进行β-内酰胺酶基因分型。主要病原菌为大肠埃希菌（34.5%）和肺炎克雷伯菌（21.2%）。医院获得性cIAI患者的大肠杆菌感染率较低（26.0% vs 49.1%; P
Background. Carbapenem-resistant Enterobacteriaceae (CRE) infections are associated with poor patient outcomes. Data on risk factors and molecular epidemiology of CRE in complicated intra-abdominal infections (cIAI) in China are limited. This study examined the risk factors of cIAI with CRE and the associated mortality based on carbapenem resistance mechanisms.Methods. In this retrospective analysis, we identified 1024 cIAI patients hospitalized from January 1, 2013 to October 31, 2018 in 14 intensive care units in China. Thirty CRE isolates were genotyped to identify beta-lactamase-encoding genes.Results. Escherichia coli (34.5%) and Klebsiella pneumoniae (21.2%) were the leading pathogens. Patients with hospital-acquired cIAI had a lower rate of E coli (26.0% vs 49.1%; P