Similar effects of NPY on energy metabolism and on plasma insulin in adrenalectomized ob/ob and lean mice.
Similar effects of NPY on energy metabolism and on plasma insulin in adrenalectomized ob/ob and lean mice.
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DOI：
10.1152/ajpendo.1993.264.2.e226
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发表时间：
1993-02
期刊：
影响因子：
--
通讯作者：
H. Walker;D. Romsos
中科院分区：
文献类型：
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作者：
H. Walker;D. Romsos
单次侧脑室 (icv) 注射地塞米松 (250 ng) 可降低肾上腺切除的 ob/ob 小鼠的棕色脂肪组织 (BAT) 生热作用和全身代谢率，并在 30 分钟内提高血浆胰岛素浓度，而对肾上腺切除的瘦小鼠的影响最小。本研究旨在确定脑室内神经肽 Y（NPY）（一种部分受糖皮质激素调节的神经肽）是否会在这些小鼠中模拟地塞米松的作用。与地塞米松类似，NPY 在 30 分钟内降低了肾上腺切除的 ob/ob 小鼠的 BAT 代谢和全身耗氧量，并提高了血浆胰岛素浓度；但是，与地塞米松不同的是，NPY 在调节去肾上腺瘦小鼠的这些代谢反应方面与 ob/ob 小鼠一样有效。此外，脑室内 NPY 增加了 ob/ob 小鼠和瘦小鼠的食物摄入量，而地塞米松在注射后 30 分钟内没有改变食物摄入量。这些数据与以下假设一致：NPY 介导 ob/ob 小鼠脑室内地塞米松作用的一些影响，并且 ob/ob 和瘦小鼠之间的差异在于糖皮质激素对 NPY 释放/合成的控制，而不是 NPY 作用机制。
A single intracerebroventricular (icv) injection of dexamethasone (250 ng) lowers brown adipose tissue (BAT) thermogenesis and whole body metabolic rates and raises plasma insulin concentrations within 30 min in adrenalectomized ob/ob mice with minimal effects in adrenalectomized lean mice. The present study was conducted to determine if intracerebroventricular neuropeptide Y (NPY), a neuropeptide regulated in part by glucocorticoids, would mimic effects of dexamethasone in these mice. NPY lowered BAT metabolism and whole body oxygen consumption and raised plasma insulin concentrations within 30 min in adrenalectomized ob/ob mice similarly to dexamethasone; but, unlike dexamethasone, NPY was as effective in modulating these metabolic responses in adrenalectomized lean mice as in ob/ob mice. Further, intracerebroventricular NPY increased food intake equally in both ob/ob and lean mice, whereas dexamethasone did not alter food intake during the 30 min postinjection period. These data are consistent with the hypothesis that NPY mediates some of the effects of intracerebroventricular dexamethasone action in ob/ob mice and that the divergence between ob/ob and lean mice lies in glucocorticoid control of NPY release/synthesis rather than in NPY action mechanisms.