Causal model of insight and psychopathology based on the PANSS factors: 1-year cross-sectional and longitudinal revalidation
Causal model of insight and psychopathology based on the PANSS factors: 1-year cross-sectional and longitudinal revalidation
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DOI：
10.1097/yic.0b013e32832d6bca
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发表时间：
2009-07-01
影响因子：
2.6
通讯作者：
Kim, Yong Sik
中科院分区：
文献类型：
--
作者：
Hwang, Samuel Suk-Hyun;Chang, Jae Seung;Kim, Yong Sik
这项研究提出了一项为期1年的精神分裂症洞察力因果模型随访调查的结果，该调查使用了早期研究中开始或改用氨硫pride的急性患者亚样本。采用结构方程建模的方法，以正、负、自闭关注因子为主要预测因子，以激活因子为中介变量，建立了基于正、负综合征量表因子的洞察力因果模型，对稳定期（8周）和慢性期（1年）的洞察力适应度进行了检验。结果表明，影响洞察力的因素和回归系数之间的相关程度发生了变化，但对于适应度指数接近完美的两个阶段，我们的洞察力假设模型的有效性仍然得到了证实。模型的适应度也证实了纵向变化的洞察力和精神病理得分。另一个模型，其中包括焦虑/抑郁因素作为第二个中介变量之间的洞察力和积极和消极因素，也被发现是有效的两个阶段。一个带有焦虑/抑郁因素的事后因果模型显示了初步的证据，表明焦虑/抑郁变量对洞察力的预测比相反的预测更有利。中国临床精神药物杂志，24 (C) 2009。
This study presents results of a 1-year follow-up investigation of the causal model of insight in schizophrenia using a subsample of acute patients starting or switching to amisulpride included in an earlier study. Our causal model of insight based on the Positive and Negative Syndrome Scale factors, with the positive, negative, and autistic preoccupation factors designated as the primary predictors, and the activation factor as a mediating variable of insight was examined for fitness at the stabilized stage (8 week) and at the chronic stage (1 year) using the structural equation modeling method. Results showed that the intercorrelations among the factors and regression coefficients toward insight changed in their magnitudes, but the validity of our hypothesized model of insight was still confirmed for both the stages with nearly perfect goodness-of-fitness indices. The fitness of the model was also confirmed for the longitudinal changes in the scores of insight and psychopathology. An alternative model, which included the anxiety/depressive factor as a second mediating variable between insight and the positive and negative factors, was also found to be valid for both the stages. A post-hoc causal model with anxiety/depressive factor showed tentative evidence favoring anxiety/depressive variable predicting insight than the other way around. Int Clin Psychopharmacol 24:189-198 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.