Adenovirus infection and subsequent risk of Kawasaki disease: A population-based cohort study
Adenovirus infection and subsequent risk of Kawasaki disease: A population-based cohort study
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DOI：
10.1097/jcma.0000000000000266
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发表时间：
2020-03-01
影响因子：
3
通讯作者：
Wei, James Cheng-Chung
中科院分区：
文献类型：
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作者：
Huang, Shih-Hui;Chen, Chun-Yu;Wei, James Cheng-Chung
背景：腺病毒感染与川崎的关系尚不清楚。本研究的目的是确定腺病毒感染和KD之间的关系，使用队列研究在Taiwan.Methods：我们使用台湾全民健康保险数据（2000年至2008年）进行了一项基于人群的队列研究，分析18岁以下的儿童。共对5280例腺病毒感染儿童和5280例无腺病毒感染儿童进行匹配和随访。随后的KD是主要结局事件。采用考克斯比例风险模型估计腺病毒感染相关KD的风险比（HR）及其95%可信区间（CI）。结果：腺病毒感染组KD的累积发病率显著高于对照组（log-rank检验，p < 0.001）。在腺病毒感染队列中，KD的总体发生率是对照队列的5.29倍（校正HR 5.29，95% CI：2.48-11.3）。KD风险增加与以前的腺病毒感染在3-5岁的儿童，女性患者，在那些城市化水平低，在那些allergis.Conclusion：以前的腺病毒感染和KD之间的关联被确定在台湾儿童，但其他潜在的危险因素没有得到充分的分析。感染与KD的关系有待进一步研究。
Background:The relationship between adenovirus infection and Kawasaki disease (KD) is unclear. The purpose of this study was to determine the relationship between adenovirus infection and KD using a cohort study in Taiwan.Methods:We used Taiwan National Health Insurance data (from 2000 to 2008) to conduct a population-based cohort study, analyzing children that was under 18 years of age. In total, 5280 children had adenovirus infection, and 5280 children without adenovirus infection were matched and followed up. Subsequent KD was the major outcome event. The Cox proportional hazards model was used to estimate the hazard ratio (HR) with 95% confidence intervals (CIs) of developing KD associated with adenovirus infection.Results:There was a significantly higher cumulative incidence of KD in the adenovirus-infected cohort than that in the control cohort (log-rank test, p < 0.001). In the adenovirus-infected cohort, overall incidence of KD was 5.29 times higher than that of the control cohort (adjusted HR 5.29, 95% CI: 2.48-11.3). Increased KD risk was associated with previous adenovirus infection in children aged 3-5 years, in female patients, in those with a low urbanization level, and in those with allergies.Conclusion:An association between previous adenovirus infection and KD was identified in Taiwanese children, but other potential risk factors were not fully analyzed. The relationship between infection and KD requires further study.