β-Resorcylic Acid Lactones from a Paecilomyces Fungus
β-Resorcylic Acid Lactones from a Paecilomyces Fungus
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DOI：
10.1021/np900853n
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发表时间：
2010-05-01
影响因子：
5.1
通讯作者：
Wei, Xiaoyi
中科院分区：
文献类型：
--
作者：
Xu, Liangxiong;He, Zhengxiang;Wei, Xiaoyi
从拟青霉（Paecilomycessp.）SC 0924的菌丝体固体培养物中分离得到6个新的β-间苯二酚内酯（1-6），命名为拟青霉霉素A-F，以及已知的活性化合物：阿吉霉素B（7），玉米烯醇（8），阿吉霉素D（9），阿吉霉素F（10）和阿吉螺醇（aigialospirol）。通过核磁共振分析、单晶X-射线衍射和化学关联等手段对化合物的结构进行了表征。化合物5和10对恶性疟原虫品系3D 7表现出抗疟原虫活性，IC（50）值分别为20.0和10.9 nM，化合物5-7对恶性疟原虫品系Dd 2表现出中等活性。
Six new beta-resorcylic acid lactones (1-6), named paecilomycins A-F, and live known compounds, aigilomycin B (7), zeaenol (8), aigialomycin D (9), aigialomycin F (10), and aigialospirol, were isolated from the mycelial solid culture of Paecilomyces sp. SC0924. Their structures were elucidated by extensive NMR analysis, single-crystal X-ray study, and chemical correlations. Compounds 5 and 10 exhibited antiplasmodial activity against Plasmodium falciparum line 3D7 with IC(50) values of 20.0 and 10.9 nM, respectively, and compounds 5-7 showed moderate activity against the P. falciparum line Dd2.