Highly Stereoselective Synthesis of Cyclopropylphosphonates Catalyzed by Chiral Ru(II)-Pheox Complex
Highly Stereoselective Synthesis of Cyclopropylphosphonates Catalyzed by Chiral Ru(II)-Pheox Complex
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DOI：
10.1021/ol501135p
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发表时间：
2014-06-06
期刊：
影响因子：
5.2
通讯作者：
Iwasa, Seiji
中科院分区：
文献类型：
--
作者：
Chanthamath, Soda;Ozaki, Seiya;Iwasa, Seiji
Ru(II)- pheo催化的二乙基重氮甲基膦酸二乙酯与烯烃（包括α、β -不饱和羰基化合物）的不对称环丙化反应，获得了相应的高收率、优异的非对映选择性（高达99:1）和对映选择性（高达99% ee）的光学活性环丙基膦酸盐。
Ru(II)-Pheox-catalyzed asymmetric cyclopropanation of diethyl diazomethylphosphonate with alkenes, including alpha,beta-unsaturated carbonyl compounds, afforded the corresponding optically active cyclopropylphosphonates in high yields and with excellent diastereoselectivity (up to 99:1) and enantioselectivity (up to 99% ee).