Vitamin D, tuberculin skin test conversion, and latent tuberculosis in Mongolian school-age children: a randomized, double-blind, placebo-controlled feasibility trial
Vitamin D, tuberculin skin test conversion, and latent tuberculosis in Mongolian school-age children: a randomized, double-blind, placebo-controlled feasibility trial
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DOI：
10.3945/ajcn.112.034967
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发表时间：
2012-08-01
影响因子：
7.1
通讯作者：
Willett, Walter C.
中科院分区：
文献类型：
--
作者：
Ganmaa, Davaasambuu;Giovannucci, Edward;Willett, Walter C.
背景：维生素D可能通过调节免疫功能提高天然免疫功能，抑制初始细菌入侵的生长，预防结核病感染。目的：观察补充维生素D对结核菌素皮肤试验(TST)转阴的影响。设计：对120名蒙古族学龄儿童进行双盲、安慰剂对照研究。结果：基线时，(+/-SD)25(OH)D平均浓度为7+/-4 ng/mL，所有浓度均为20 ng/mL，而最终25(OH)D浓度保持不变的患者发生了8次TST转换
Background: By modulating immune function, vitamin D might increase innate immunity and inhibit the growth of initial bacterial invasion and protect against tuberculosis infection.Objective: We examined the effect of vitamin D supplementation on tuberculin skin test (TST) conversion.Design: A double-blind, placebo-controlled study was conducted in 120 Mongol schoolchildren. We estimated the prevalence of latent tuberculosis infection at baseline and examined the effect of vitamin D (800 IU/d) on serum concentrations of 25-hydroxyvitamin D [25(OH)D] and TST conversion.Results: At baseline, the mean (+/- SD) 25(OH)D concentration was 7 +/- 4 ng/mL, and all concentrations were 20 ng/mL, whereas 8 TST conversions occurred in those whose final 25(OH)D concentration remained