Increased serum Th2 chemokine levels are associated with bronchopulmonary dysplasia in premature infants
Increased serum Th2 chemokine levels are associated with bronchopulmonary dysplasia in premature infants
复制标题
血清 Th2 趋化因子水平升高与早产儿支气管肺发育不良有关
DOI：
10.1007/s00431-018-3266-z
复制
发表时间：
2019-01-01
影响因子：
3.6
通讯作者：
Liu, Hanmin
中科院分区：
文献类型：
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作者：
Zhou, Dan;Shi, Fang;Liu, Hanmin
支气管肺发育不良（BPD）是早产儿最常见的慢性炎症性肺病之一，具有严重的短期和长期后果。早期识别有BPD风险的早产儿对预防疾病的发病至关重要。因此，在本研究中，我们招募了126名早产儿，在生命早期的不同时间点收集外周血样本，并测量血清中Th 1（MCP-1，IP-10和Th 2）和Th 2（Eotaxin-1，Eotaxin-2和MCP-4）趋化因子的浓度。我们发现BPD组在出生后第1天[1662 pg/ml vs. 1221 pg/ml，P< 0.05]、第7天[1533 pg/ml vs. 1089 pg/ml，P <0.05]和第14天[1246 pg/ml vs. 704 pg/ml，P< 0.05]的血清嗜酸性粒细胞趋化因子-2水平显著高于非BPD组，BPD组的血清MCP-4水平在第1天[186 pg/ml对128 pg/ml，P< 0.05]、第7天[199 pg/ml对101 pg/ml，P< 0.05]和第14天[238 pg/ml对106 pg/ml，结论：Th 2趋化因子Eotaxin-2和MCP-4水平升高与早产儿BPD相关。已知：BPD的发病机制是多因素的，难以预测和预防。以往的研究表明，炎症在BPD的发病机制中起着重要作用。新发现：·Th 2趋化因子Eotaxin-2和MCP-4的增加与早产儿的BPD有关。·早期Th 1/Th 2反应异常可能与BPD的发生、发展有关，这为了解BPD的发病机制提供了新的思路。
Bronchopulmonary dysplasia (BPD) is one of the most common chronic inflammatory lung disease of premature infants, with serious short- and long-term consequences. Early identification of premature infants at risk of BPD is critical to preventing the pathogenesis of disease. Thus, in the present study, we recruited 126 premature infants, collected peripheral blood samples at different time points during early life, and measured the concentration of Th1 (MCP-1, IP-10, and MIG) and Th2 (eotaxin-1, eotaxin-2, and MCP-4) chemokines in serum. We found serum eotaxin-2 levels were significantly higher in the BPD group than in the non-BPD group on day 1 [1662 pg/ml vs. 1221 pg/ml,P< 0.05], day 7 [1533 pg/ml vs. 1089 pg/ml,P< 0.05], and day 14 [1246 pg/ml vs. 704 pg/ml,P< 0.05] after birth, and serum MCP-4 levels were also significantly higher in the BPD group than in the non-BPD group on day 1 [186 pg/ml vs. 128 pg/ml,P< 0.05], day 7 [199 pg/ml vs. 101 pg/ml,P< 0.05], and day 14 [238 pg/ml vs. 106 pg/ml,P< 0.05] of life.Conclusions: Increased levels of Th2 chemokines, eotaxin-2, and MCP-4, are associated with BPD in premature infants.What is Known:•The pathogenesis of BPD is multifactorial and it is difficult to predict and prevent.•Previous studies have demonstrated that inflammation plays a major role in the pathogenesis of BPD.What is New:•Increased Th2 chemokines, eotaxin-2 and MCP-4, were associated with BPD in premature infants.•Abnormal Th1/Th2 response in early life maybe associated with the subsequent development of BPD, which provide a new insight to understand the pathogenesis of the disease.