Impacts of high-sucrose diet on circadian rhythms in the small intestine of rats
Impacts of high-sucrose diet on circadian rhythms in the small intestine of rats
复制标题
高糖饮食对大鼠小肠昼夜节律的影响
DOI：
10.1080/07420528.2019.1592185
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发表时间：
2019
影响因子：
2.8
通讯作者：
Oda Hiroaki
中科院分区：
文献类型：
--
作者：
Sun Shumin;Hanzawa Fumiaki;Umeki Miki;Matsuyama Yasuko;Nishimura Naomichi;Ikeda Saiko;Mochizuki Satoshi;Oda Hiroaki
过量的蔗糖摄入，被称为果糖中毒，导致脂肪肝，高脂血症和代谢综合征。昼夜节律紊乱也会导致代谢综合征。在这里，我们研究了过量蔗糖摄入对小肠（蔗糖吸收的主要位置）昼夜节律的影响，以阐明蔗糖诱导的脂质代谢异常的机制。雄性Wistar大鼠喂食对照淀粉或高糖饮食4周。高糖饮食诱发大鼠脂肪肝及高脂血症。过量蔗糖降低小肠PER 1/2表达波动幅度，同时增强GLUT 5和促消化酶基因表达。这些变化将有助于干预脂质稳态以及适应性反应，以控制大鼠果糖毒性。
Excessive sucrose intake, known as fructose toxicity, leads to fatty liver, hyperlipidemia, and metabolic syndrome. Circadian disorders also contribute to metabolic syndrome. Here, we investigated the effect of excessive sucrose intake on circadian rhythms of the small intestine, the main location of sucrose absorption, to elucidate a mechanism of sucrose-induced abnormal lipid metabolism. Male Wistar rats were fed control starch or high-sucrose diets for 4 weeks. High-sucrose diet-induced fatty liver and hypertriglyceridemia in rats. Amplitudes ofPER1/2expression oscillations in the small intestine were reduced by excessive sucrose, while gene expression of GLUT5 and gluconeogenic enzymes was enhanced. These changes would contribute to interfering in lipid homeostasis as well as adaptive responses to control fructose toxicity in rats.