Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data
Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data
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DOI：
10.1016/s1525-1578(10)60495-3
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发表时间：
2004-05-01
影响因子：
4.1
通讯作者：
Yatabe, Y
中科院分区：
文献类型：
--
作者：
Koga, T;Horio, Y;Yatabe, Y
乳腺癌患者发生第二原发癌的风险增加。肺是主要靶器官之一，因此，在有乳腺癌病史的患者中，治疗肺肿瘤需要对原发性和转移性癌症进行鉴别诊断。然而，活检标本经常导致小的、碎片化的组织，仅含有少量退化的癌细胞。我们试图找到一个有用的标志物鉴别诊断，使用在线SAGE数据库。我们选择了三种分子，小乳腺上皮粘蛋白（SBEM），前列腺上皮特异性Ets转录因子（PDEF）和乳房珠蛋白（MGB1），作为乳腺癌的潜在标志物。SBEM和PDEF被证明对实际鉴别诊断没有用处，因为它们在正常支气管中表达。与此相反，MGB1在所有22例原发性乳腺癌中均检测到表达，而在22例正常肺组织中未检测到表达。此外，所有12例转移性乳腺癌检查显示阳性MGB1转录，而48例原发性肺腺癌表达MGB1。这表明MGB 1可以作为一种差异分子标记。在实践中，前瞻性检查，使用9例乳腺癌病史，证实了MGB1的鉴别诊断的有用性。
The risk of developing second primary cancers is increased in patients with breast cancer. The lung is one of the major target organs, and therefore a differential diagnosis between primary and metastatic cancers is required for the treatment of lung tumors in patients with a history of breast cancer. However, biopsy specimens frequently result in small, fragmented tissues containing only a few, degenerated cancer cells. We attempted to find a useful marker for differential diagnosis, using the online SAGE database. We selected three molecules, small breast epithelial mucin (SBEM), prostate epithelium-specific Ets transcription factor (PDEF), and mammaglobin (MGB1), as potential markers for breast cancer. SBEM and PDEF proved of no use for practical differential diagnosis because they are expressed in the normal bronchus. In contrast, expression of MGB1 was detected in all 22 primary breast cancers, but not in 22 normal lung tissues. Furthermore, all 12 metastatic breast cancers examined demonstrated positive MGB1 transcripts, whereas one of 48 primary lung adenocarcinomas expressed MGB1. This suggests that MGB1 can serve as a differential molecular marker. In practice, prospective examination, using the nine cases with a history of breast cancer, confirmed the usefulness of MGB1 in differential diagnosis.