ENHANCEMENT OF WOUND-HEALING BY TOPICAL TREATMENT WITH EPIDERMAL GROWTH-FACTOR
ENHANCEMENT OF WOUND-HEALING BY TOPICAL TREATMENT WITH EPIDERMAL GROWTH-FACTOR
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DOI：
10.1056/nejm198907133210203
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发表时间：
1989-07-13
影响因子：
158.5
通讯作者：
LYNCH, JB
中科院分区：
文献类型：
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作者：
BROWN, GL;NANNEY, LB;LYNCH, JB
在动物身上的实验研究表明，局部应用表皮生长因子可以加速部分创面和二度烧伤的表皮再生。我们结束了一项使用皮肤移植供体部位的前瞻性、随机、双盲临床试验，以确定表皮生长因子是否会加速人类表皮再生的速度。在12名烧伤或重建手术需要皮肤移植的患者中，创建了配对的供体部位。每个患者的一个供体部位用磺胺嘧啶银霜局部治疗，另一个用含有表皮生长因子的磺胺嘧啶银霜(每毫升10微克)治疗。每天拍摄供体部位的照片，并使用平面分析测量愈合情况。在12例患者中，含表皮生长因子的磺胺嘧啶银组供区的表皮再生速度均快于单用磺胺嘧啶银组。使用表皮生长因子治疗可将平均愈合时间缩短至25%和50%，缩短约一天，缩短至75%和100%，缩短约1.5天(P<；0.02)。在愈合开始三天后，从供体部位中心采集的穿孔活检标本的组织学评估支持这些结果。我们的结论是，表皮生长因子加速了部分厚度皮肤创面的愈合速度。需要进一步的研究来确定这一发现的临床重要性。
Experimental studies in animals have demonstrated that the topical application of epidermal growth factor accelerates the rate of epidermal regeneration of partial-thickness wounds and second-degree burns. We concluded a prospective, randomized, double-blind clinical trial using skin-graft-donor sites to determine whether epidermal growth factor would accelerate the rate of epidermal regeneration in humans. Paired donor sites were created in 12 patients who required skin grafting for either burns or reconstructive surgery. One donor site from each patient was treated topically with silver sulfadiazine cream, and one was treated with silver sulfadiazine cream containing epidermal growth factor (10 .mu.g per milliliter). The donor sites were photographed daily, and healing was measured with the use of planimetric analysis. The donor sites treated with silver sulfadiazine containing epidermal growth factor had an accelerated rate of epidermal regeneration in all 12 patients as compared with that in the paired donor sites treated with silver sulfadiazine alone. Treatment with epidermal growth factor significantly decreased the average length of time to 25 percent and 50 percent healing by approximately one day and that to 75 percent and 100 percent healing by approximately 1.5 days (P < 0.02). Histologic evaluation of punch-biopsy specimens taken from the centers of donor sites three days after the onset of healing supported these results. We conclude that epidermal growth factor accelerates the rate of healing of partial-thickness skin wounds. Further studies are required to determine the clinical importance of this finding.