25-HYDROXYVITAMIN-D LEVELS DURING BREAST-FEEDING WITH OR WITHOUT MATERNAL OR INFANTILE SUPPLEMENTATION OF VITAMIN-D
25-HYDROXYVITAMIN-D LEVELS DURING BREAST-FEEDING WITH OR WITHOUT MATERNAL OR INFANTILE SUPPLEMENTATION OF VITAMIN-D
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DOI：
10.1097/00005176-198504000-00011
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发表时间：
1985-01-01
影响因子：
2.9
通讯作者：
ALAHOUHALA, M
中科院分区：
文献类型：
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作者：
ALAHOUHALA, M
对100对不同维生素D补充方案的健康足月儿进行了母乳喂养的婴儿及其母亲血清25-羟维生素D（25-OHD）、钙、磷、镁和碱性磷酸酶水平的研究。在冬季进行的一项试点研究显示，8个母乳喂养的婴儿中有6个没有补充维生素D，在8周龄时血清25-OHD水平低于佝偻病的风险限度（5 ng/ml）。在冬季组的主要研究中，发现25-OHD水平较低（5.6 ± 0.01）。3.7 ng/ml），其母亲在哺乳期补充维生素D 1，000 IU/天（第I组）的未补充母乳喂养婴儿在8周时的水平，与接受400 IU/天（18.0 . ±. 8.4 ng/ml，组II）或1000 IU（22.8 ±. 11.2 ng/ml，III组）维生素D（I组与II或III组，P < 0.001; II组与III组，NS）。在I组中，18名婴儿中有10名血清25-OHD水平< 5 ng/ml，而在II组和III组中没有婴儿。而25-OHD水平< 5 ng/ml的婴儿在8或20周龄时未出现临床或生化佝偻病体征。在夏季分娩的母亲25-OHD水平是好的，但此后下降。此外，在夏季组中，婴儿25-OHD浓度下降;然而，由于分娩时的水平较高，它们保持在正常范围内。在冬季阳光不足的国家，单独母乳喂养或母亲补充1000 IU/天维生素D可能会导致儿童的25-OHD水平非常低。每天补充400国际单位的维生素D似乎对缺乏阳光照射的母乳喂养婴儿是足够的。
Serum 25-hydroxyvitamin D (25-OHD), Ca, P, Mg and alkaline phosphatase levels of breast-fed infants and their mother were studied by following 100 healthy term mother-infant pairs with different supplementation protocols of vitamin D. A pilot study in winter revealed that 6 of 8 breast-fed infants without vitamin D supplementation had serum 25-OHD levels below the risk limit for rickets (5 ng/ml) at the age of 8 wk. In the main study in winter groups, it was found that the 25-OHD levels were low (5.6 .+-. 3.7 ng/ml) at the age of 8 wk in the unsupplemented breast-fed infants, whose mothers were given vitamin D supplementation of 1,000 IU/day during lactation (group I), compared with the levels of those infants receiving either 400 (18.0 .+-. 8.4 ng/ml, group II) or 1000 IU (22.8 .+-. 11.2 ng/ml, group III) vitamin D (group I vs. group II or III, P < 0.001; group II vs. group III, NS). In group I 10 of 18 infants had serum 25-OHD levels < 5 ng/ml compared with none of the infants in groups II and III. Yet the infants with 25-OHD levels < 5 ng/ml showed on signs of clinical or biochemical rickets at the age of 8 or 20 wk. In summer at delivery the maternal 25-OHD levels were good, but decreased thereafter. Also in summer groups, the infantile 25-OHD concentrations decreased; however, because the levels at delivery were high, they stayed in the normal range. In a country with scant sunlight in winter, breast feeding alone or with maternal supplementation of 1000 IU/day vitamin D may lead to very low 25-OHD levels in the child. A vitamin D supplement of 400 IU/day appears adequate for breast-fed infants during scarce exposure to sunlight.