Neuropathological alteration of aquaporin 1 immunoreactive enteric neurons in the streptozotocin-induced diabetic rats
Neuropathological alteration of aquaporin 1 immunoreactive enteric neurons in the streptozotocin-induced diabetic rats
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DOI：
10.1016/j.autneu.2007.09.002
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发表时间：
2008-02-29
影响因子：
2.7
通讯作者：
Narita, Masaaki
中科院分区：
文献类型：
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作者：
Ishihara, Eriko;Nagahama, Masato;Narita, Masaaki
长期糖尿病患者表现出腹泻和便秘等主要临床胃肠道问题。近年来，人们在肠神经系统（ENS）中发现了水通道蛋白水通道蛋白1 （AQP1）。我们观察了链脲佐菌素（STZ）诱导的糖尿病大鼠AQP1免疫反应（IR）神经元的病理变化。给8周龄Wistar大鼠注射链脲佐菌素，诱导人工糖尿病。16周龄STZ大鼠采用双免疫荧光染色和ABC免疫组化染色。STZ大鼠AQP1-IR神经元较对照大鼠明显增加(p
Long-term diabetic patients exhibit major clinical gastrointestinal problems, such as diarrhea and constipation. In recent years, water channel protein, aquaporin 1 (AQP1) has been identified in the enteric nervous system (ENS). We have examined the pathological changes in AQP1 immunoreactive (IR) neurons in streptozotocin-induced (STZ) diabetic rats. Eight-week-old Wistar rats were injected with streptozotocin, and artificial diabetes was induced. Sixteen-week-old STZ rats were then examined with double immunofluorescence staining and ABC immunohistochemical staining. AQP1-IR neurons in STZ rats were significantly increased compared with control rats (p