Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo
Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo
复制标题
DOI：
10.1038/nature02418
复制
发表时间：
2004-03-25
期刊：
影响因子：
64.8
通讯作者：
Meno, C
中科院分区：
文献类型：
--
作者：
Yamamoto, M;Saijoh, Y;Meno, C
小鼠胚胎沿着前后轴的图案在身体计划的发展需要远端内脏内胚层（DVE）向未来的前侧迁移的机制，一直是未知的。在这里，我们表明，Nodal信号和区域化的拮抗剂是所需的正常迁移的DVE。Nodal信号通过刺激内脏内胚层细胞的增殖为DVE迁移提供驱动力，而拮抗剂Lefty1和Cerl通过不对称地抑制未来前侧的Nodal活性来确定迁移方向。
Patterning of the mouse embryo along the anteroposterior axis during body plan development requires migration of the distal visceral endoderm (DVE) towards the future anterior side by a mechanism that has remained unknown. Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE. Whereas Nodal signalling provides the driving force for DVE migration by stimulating the proliferation of visceral endoderm cells, the antagonists Lefty1 and Cerl determine the direction of migration by asymmetrically inhibiting Nodal activity on the future anterior side.