Lymphoid neo-organogenesis - Lymphotoxin's role in inflammation and development
Lymphoid neo-organogenesis - Lymphotoxin's role in inflammation and development
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DOI：
10.1007/bf02786481
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发表时间：
1999-01-01
影响因子：
4.4
通讯作者：
Ruddle, NH
中科院分区：
文献类型：
--
作者：
Ruddle, NH
类扁桃体器官发育和炎症以前被认为是不同的机制和功能。近年来，人们认识到这些现象有许多共同之处。这一认识来自于对光敏素（LT）/肿瘤坏死因子（TNF）家族的细胞因子参与这两个过程的认识。该家族的成员LT-α、LT-β和TNF-α及其多种受体联合参与淋巴器官发育和慢性炎症。当微生物感染或自身免疫性疾病引起的炎症变成慢性时，它可以呈现有组织的淋巴组织的外观，并被称为三级淋巴器官。转基因和基因敲除小鼠的数据表明，该过程是由精氨酸介导的，可以称为“淋巴新生器官形成”，LT作为LT-α（3）和LT-α（1）β（2）在这些过程中起关键作用。在体外内皮细胞系和体内转基因和基因敲除小鼠中获得的数据表明，LT通过诱导粘附分子如E-选择素粘附分子（ELAM）、血管细胞粘附分子（VCAM）、细胞间粘附分子（ICAM）、粘膜地址素细胞粘附分子（MAdCAM）和外周淋巴结地址素（PNAd）和趋化因子来影响这些事件。
Lymphoid organ development and inflammation have previously been considered as distinct mechanistically and functionally. In recent years, it has been realized that these phenomena have much in common. This insight has been gained from the recognition that cytokines of the lymphotoxin (LT)/tumor necrosis factor (TNF) family are involved in both processes. The members of the family, LT-alpha, LT-beta, and TNF-alpha, and their multiple receptors participate combinatorially in lymphoid organ development and chronic inflammation. When inflammation that arises in microbial infection or autoimmune disease becomes chronic, it can take on the appearance of organized lymphoid tissue and has been called a tertiary lymphoid organ. Data with transgenic and knockout mice suggest that the process is cytokine-mediated and could be called "lymphoid neo-organogenesis," LT as LT-alpha(3) and LT-alpha(1)beta(2) plays a key role in these processes. Data obtained in vitro in an endothelial cell line and in vivo in transgenic and knockout mice indicate that LT influences these events through induction of adhesion molecules such as E-selectin adhesion molecule (ELAM), vascular cell adhesion molecule (VCAM), intercellular adhesion molecule (ICAM), mucosal addressin cellular adhesion molecule (MAdCAM), and peripheral node addressin (PNAd), and chemokines.