NAVIGATIONAL SUBSTRATES FOR PERIPHERAL PIONEER GROWTH CONES - LIMB-AXIS POLARITY CUES, LIMB-SEGMENT BOUNDARIES, AND GUIDEPOST NEURONS
NAVIGATIONAL SUBSTRATES FOR PERIPHERAL PIONEER GROWTH CONES - LIMB-AXIS POLARITY CUES, LIMB-SEGMENT BOUNDARIES, AND GUIDEPOST NEURONS
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DOI：
10.1101/sqb.1983.048.01.062
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
CAUDY, M
中科院分区：
文献类型：
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作者：
BENTLEY, D;CAUDY, M
神经细胞通常与中枢神经系统内和外周远处的目标细胞建立精确的突触连接。在胚胎发育过程中，轴突生长锥必须从细胞体位置长距离导航到靶细胞位置才能建立这些连接。我们对生长锥导航的发育机制感兴趣。蚱蜢胚胎发生为研究中枢神经系统和外周之间长距离神经通路的形成提供了一个不寻常的机会。当胚胎肢芽开始从体壁外凸时，它们最初没有神经元。肢体中的第一个神经细胞是传入（感觉）神经元（称为“先锋”），它们产生于肢体上皮内并向中枢神经系统投射轴突（Bate 1976；Keshishian 1980a）。先锋生长锥首先穿过肢体，在第一个传出生长锥出现时到达中枢神经系统，从而建立穿过肢体的初始神经路线。
Nerve cells often establish precise synaptic connections with target cells at distant locations, both within the CNS and in the periphery. During embryonic development, axonal growth cones have to navigate over long distances from the site of the cell body to the site of the target cell to establish these connections. We are interested in the developmental mechanisms underlying growth cone navigation.Grasshopper embryogenesis offers an unusual opportunity for studying the formation of long-distance neural pathways between the CNS and the periphery. As embryonic limb buds begin to evaginate from the body wall, they are initially devoid of neurons. The first nerve cells in the limb are afferent (sensory) neurons (termed" pioneers"), which arise within the limb epithelium and project axons toward the CNS (Bate 1976; Keshishian 1980a). The pioneer growth cones are the first to traverse the limb, reaching the CNS just as the first efferent growth cones are emerging and thus establishing the initial nerve routes through the limb.