Impairment of contrast visual acuity as a functional correlate of retinal nerve fibre layer thinning and total macular volume reduction in multiple sclerosis
Impairment of contrast visual acuity as a functional correlate of retinal nerve fibre layer thinning and total macular volume reduction in multiple sclerosis
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DOI：
10.1136/bjo.2010.193581
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发表时间：
2012-01-01
影响因子：
4.1
通讯作者：
Paul, Friedemann
中科院分区：
文献类型：
--
作者：
Bock, Markus;Brandt, Alexander U.;Paul, Friedemann
目的分析复发-缓解型多发性硬化（MS）患者视网膜神经纤维层厚度（RNFLT）与光学相干断层扫描（OCT）测量的黄斑总体积（TMV）及功能性视力对比测试（FACT）测量的对比敏感度（CS）的关系;并研究在多发性硬化症（MS）中通过对比盒装置进行FACT测试是否可行方法采用Optec 6500 P视力测试系统，在无眩光的明视和中间视条件下，进行最佳矫正的FACT检查。计算了对数对比敏感度函数下的面积（AUC）。RNFLT和TMV通过Stratus光学相干断层扫描进行评估。结果85例（170眼）复发缓解型多发性硬化患者和35例（70眼）健康对照者进行了视力检查（Snellen法）、球镜屈光不正检查和柱镜屈光不正检查。MS患者的昼夜AUC低于HC患者（p
Objectives To analyse the association between retinal nerve fibre layer thickness (RNFLT) and total macular volume (TMV) as measured by optical coherence tomography, and contrast sensitivity (CS) measured by Functional Acuity Contrast Testing (FACT) in relapsing-remitting multiple sclerosis; and to investigate whether FACT testing by a contrast box device is feasible in multiple sclerosis (MS).Methods FACT was performed using the Optec 6500 P vision testing system with best correction under photopic and mesopic conditions without glare. The Area Under the Log Contrast Sensitivity Function (AUC) was calculated. RNFLT and TMV were assessed by Stratus optical coherence tomography. All participants underwent visual acuity testing (Snellen), spherical refractive error testing and cylindrical refractive error testing.Results 85 relapsing-remitting multiple sclerosis patients (170 eyes) and 35 healthy controls (HC, 70 eyes) were measured. AUC Day and Night were lower in MS than in HC (p