Maternal vitamin D deficiency, ethnicity and gestational diabetes
Maternal vitamin D deficiency, ethnicity and gestational diabetes
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DOI：
10.1111/j.1464-5491.2008.02422.x
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发表时间：
2008-06-01
影响因子：
3.5
通讯作者：
McElduff, A.
中科院分区：
文献类型：
--
作者：
Clifton-Bligh, R. J.;McElduff, P.;McElduff, A.
维生素D缺乏与糖代谢受损有关。我们确定是否血清25-羟基维生素D（25 OHD）与葡萄糖代谢的孕妇和种族对这种relationship.Methods的影响，我们分析了307名孕妇参加2003年10月和2005年5月之间的大都市产科诊所的血清25 OHD浓度。其中264名妇女的测量值是在妊娠中期进行葡萄糖耐量试验时进行的，因此这一人群患妊娠期糖尿病的风险增加。Pearson相关分析用于检验血清25 OHD的自然对数（ln-25 OHD）与其他变量之间的单变量线性关系。结果平均血清25 OHD浓度为53.8 ± 23.9 nmol/l（SD）。Ln-25 OHD与血清甲状旁腺激素呈负相关（r-0. 24，可信区间-0. 35 ~-0. 12）。Ln-25 OHD与空腹血糖（r-0. 20，-0. 31 ~-0. 08）、空腹胰岛素（r-0. 20，-0. 31 ~-0. 08）和胰岛素抵抗（r-0. 21，-0. 32 ~-0. 09）呈负相关。在多变量分析中，考虑种族、年龄和体重指数后，空腹血糖和对数转换的25 OHD浓度之间的相关性具有临界显著性（-0.13，-0.26至0.01）。25 OHD < 50 nmol/l的孕妇妊娠期糖尿病的优势比未达到统计学显著性（1.92，95%可信区间0.89-4.17）。结论母体25 OHD浓度与空腹血糖呈负相关，但这是否与种族背景无关还需要进一步研究。
Aims Vitamin D deficiency has been linked to impaired glucose metabolism. We determined whether serum 25-hydroxyvitamin D (25OHD) is associated with glucose metabolism in pregnant women and the effect of ethnicity on this relationship.Methods We analysed serum 25OHD concentrations in 307 pregnant women attending a metropolitan obstetric clinic between October 2003 and May 2005. Measurements from 264 of the women were taken at the time of glucose tolerance testing at mid-gestation, a population therefore at increased risk for gestational diabetes. Pearson correlation analysis was used to test for univariate linear relationships between the natural log of serum 25OHD (ln-25OHD) and other variables. Multiple regression analysis was used to adjust for confounding factors.Results Mean serum 25OHD concentration was 53.8 +/- 23.9 nmol/l (SD). Ln-25OHD was negatively correlated with serum parathyroid hormone as expected (r -0.24, confidence intervals -0.35 to -0.12). Ln-25OHD was also negatively correlated with fasting plasma glucose (r -0.20, -0.31 to -0.08), fasting insulin (r -0.20, -0.31 to -0.08) and insulin resistance as calculated by homeostatis model assessment (r -0.21, -0.32 to -0.09). The association between fasting glucose and log-transformed 25OHD concentration was of borderline significance after accounting for ethnicity, age and body mass index in multivariate analyses (-0.13, -0.26 to 0.01). The odds ratio of gestational diabetes in women with 25OHD < 50 nmol/l did not reach statistical significance (1.92, 95% confidence interval 0.89-4.17).Conclusions Maternal 25OHD concentrations are inversely related to fasting glucose, although further studies are required to establish whether this is independent of the effects of ethnic background.