Enantioselective Synthesis of Silacyclopentanes
Enantioselective Synthesis of Silacyclopentanes
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DOI：
10.1002/anie.201511728
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发表时间：
2016-05-04
影响因子：
16.6
通讯作者：
Tomooka, Katsuhiko
中科院分区：
文献类型：
--
作者：
Igawa, Kazunobu;Yoshihiro, Daisuke;Tomooka, Katsuhiko
通过氧化硅环戊烯的高对映选择性消除反应和立体定向转化反应合成了一系列功能化的硅环戊烷.通过密度泛函理论（DFT）计算，阐明了消除反应的机理.用氧官能化的硅杂环戊烷进行的体外生物测定显示出与5-羟色胺受体蛋白的实质性结合。
A variety of functionalized silacyclopentanes were synthesized by highly enantioselective -eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the -elimination was elucidated by DFT calculations. An invitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.