Dual-modality Imaging of function and physiology
Dual-modality Imaging of function and physiology
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DOI：
10.1016/s1076-6332(03)80564-0
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发表时间：
2002-11-01
影响因子：
4.8
通讯作者：
Sakdinawat, AE
中科院分区：
文献类型：
--
作者：
Hasegawa, BH;Iwata, K;Sakdinawat, AE
双模态成像是一种将计算机断层扫描（CT）或磁共振成像与正电子发射断层扫描或单光子发射CT相结合的技术，以使用集成系统采集结构和功能图像。数据是在一个单一的程序中获得的;患者在接受X射线和放射性核素研究时保持在扫描仪上，以促进结构和功能图像之间的相关性。由此产生的数据可以帮助定位，使更具体的诊断比可以获得一个传统的成像研究。此外，解剖信息可以用于补偿相关放射性核素数据的物理扰动，例如光子衰减、散射辐射和部分体积误差。因此，双模态成像提供了先验信息，其可以改善放射性核素图像的视觉质量和定量准确性。还在为涉及小动物的生物研究开发双模态成像系统。小动物双模态系统为目前通过放射自显影和组织取样进行的有创测量提供了优势。通过非侵入性采集数据，双模态成像允许在单个动物中进行系列研究，使测量能够用更少的动物进行，并提高数据的统计质量。
Dual-modality imaging is a technique in which computed tomography (CT) or magnetic resonance imaging is combined with positron emission tomography or single-photon emission CT to acquire structural and functional images with an integrated system. The data are acquired in a single procedure; the patient remains on the scanner table while undergoing both x-ray and radionuclide studies to facilitate correlation between the structural and functional images. The resulting data can aid in localization, enabling more specific diagnosis than can be obtained with a conventional imaging study. In addition, the anatomic information can be used to compensate the correlated radionuclide data for physical perturbations such as photon attenuation, scatter radiation, and partial volume errors. Thus, dual-modality imaging provides a priori information that can improve both the visual quality and the quantitative accuracy of the radionuclide images. Dual-modality imaging systems are also being developed for biologic research involving small animals. Small-animal dual-modality systems offer advantages for measurements that currently are performed invasively with autoradiography and tissue sampling. By acquiring data noninvasively, dual-modality imaging permits serial studies in a single animal, enables measurements to be performed with fewer animals, and improves the statistical quality of the data.