Neural correlates of hypothalamic-pituitary-adrenal regulation of mothers with their infants.
Neural correlates of hypothalamic-pituitary-adrenal regulation of mothers with their infants.
复制标题
DOI：
10.1016/j.biopsych.2011.06.011
复制
发表时间：
2011-11-01
影响因子：
10.6
通讯作者：
Ablow, Jennifer C
中科院分区：
文献类型：
--
作者：
Laurent, Heidemarie K;Stevens, Alexander;Ablow, Jennifer C
通过下丘脑-垂体-肾上腺（HPA）轴进行压力调节的神经相关性已经被确定，但人们对这些如何应用于现实世界的人际压力环境（例如母婴互动）知之甚少。我们通过检查与婴儿的 HPA 调节相关的母亲对婴儿哭声的神经激活来扩展压力调节研究。 22 名初产妇在功能磁共振成像扫描期间聆听了自己 18 个月婴儿的哭声、不熟悉的婴儿哭声和控制声音。在涉及陌生情境应激源的单独会话中的四个时间点收集唾液皮质醇。使用分层线性模型对皮质醇轨迹进行建模，并使用轨迹项来预测对婴儿哭声的神经反应。表现出较低 HPA 反应性（以轨迹曲率而不是水平为指标）的母亲表现出相对于边缘系统/旁边缘系统和前额叶回路的控制声音而言，婴儿哭声的激活程度更高。这些包括导水管周围灰质、右岛叶和双侧眶额皮质，以及前扣带回内侧前额叶皮质。激活在某种程度上与之前的 HPA 调节发现重叠，并且与其他母体反应范式中确定的回路更广泛地融合。母亲的压力调节涉及跨压力源类型（即前额叶）和母婴关系特有的区域（即边缘/副边缘）发现的两个回路。在定义与压力相关的神经相关因素时，母亲 HPA 反应轨迹的形状比这种反应的水平更重要。未来的研究应该考虑压力环境和生理轨迹的维度来定义压力调节回路。
Neural correlates of stress regulation via the hypothalamic-pituitary-adrenal (HPA) axis have been identified, but little is known about how these apply to real-world interpersonal stress contexts such as mother-infant interaction. We extended stress regulation research by examining maternal neural activation to infant cry related to HPA regulation with their infants. Twenty-two primiparous mothers listened to their own 18-month infant's cry sound, unfamiliar infant cry, and control sound during fMRI scanning. Salivary cortisol was collected at four timepoints in a separate session involving the Strange Situation stressor. Cortisol trajectories were modeled using hierarchical linear modeling, and trajectory terms were used to predict neural response to own infant cry. Mothers who showed less HPA reactivity – indexed by trajectory curvature, rather than level – showed increased activation to their infant's cry relative to control sound across limbic/paralimbic and prefrontal circuits. These included periaqueductal gray, right insula, and bilateral orbitofrontal cortex, as well as anterior cingulate-medial prefrontal cortex. Activations overlapped to some extent with previous HPA regulation findings, and converged more extensively with circuits identified in other maternal response paradigms. Maternal stress regulation involves both circuits found across stressor types (i.e., prefrontal) and areas unique to the mother-infant relationship (i.e., limbic/paralimbic). The shape of mothers' HPA response trajectory was more important than the level of such response in defining stress-related neural correlates. Future research should consider dimensions of the stress context and of physiological trajectories to define stress-regulatory circuits.